The effect of exercise interventions on inflammatory biomarkers in healthy, physically inactive subjects: a systematic review

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dc.contributor.author Cronin, Owen
dc.contributor.author Keohane, David M.
dc.contributor.author Molloy, Michael G.
dc.contributor.author Shanahan, Fergus
dc.date.accessioned 2017-06-23T10:56:18Z
dc.date.available 2017-06-23T10:56:18Z
dc.date.issued 2017-05-02
dc.identifier.citation Cronin, O., Keohane, D.M., Molloy, M. G. and Shanahan, F., (2017) ‘The effect of exercise interventions on inflammatory biomarkers in healthy, physically inactive subjects: a systematic review’, QJM, 110(10), pp. 629-637. doi: 10.1093/qjmed/hcx091 en
dc.identifier.volume 110
dc.identifier.issued 10
dc.identifier.startpage 629
dc.identifier.endpage 637
dc.identifier.issn 1460-2725
dc.identifier.uri http://hdl.handle.net/10468/4182
dc.identifier.doi 10.1093/qjmed/hcx091
dc.description.abstract Background: Increases in physical activity ameliorate low-grade systemic inflammation in disease populations such as type 2 diabetes mellitus and coronary artery disease. The effects of aerobic and resistance training (RT) on inflammatory biomarker profiles in non-disease, physically inactive individuals are unknown. Methods: A systematic review of randomized controlled trials measuring the effect of aerobic and resistance exercise on pro-inflammatory biomarkers in healthy, inactive adult populations was conducted. The available peer-reviewed literature was searched from January 1990 to June 2016 using the electronic databases PubMed and Scopus. A narrative synthesis of review findings was constructed with discussion of the impact of aerobic, resistance and combined training on C-reactive protein (CRP), interleukin-6 (IL-6), interleukin-8, interleukin-1β and tumour necrosis factor-α. Results: The initial search revealed 1596 potentially relevant studies. Application of the study eligibility criteria led to the full-text review of 54 articles with 11 studies deemed suitable for inclusion. Review of related articles and the reference lists of the 54 full-text articles led to the inclusion of 2 additional studies. The review revealed inconsistent findings relating to the effect of aerobic training and RT on CRP and IL-6. Studies of older-aged adults (>65 years old) demonstrated the greatest and most consistent reduction in inflammatory biomarkers post-training intervention. Conclusions: A paucity of evidence exists relating to the effect of exercise training on inflammatory markers in non-disease, physically inactive adults. The available evidence suggests potential for the greatest benefit to be seen in older populations and with higher intensity aerobic exercise. en
dc.description.sponsorship Science Foundation Ireland (SFI centre grant to the Alimentary Pharamabiotic Centre (APC) Microbiome Institute (grant no. SFI/12/RC/2273)); Irish Centre for Arthritis Research and Education (ICARE) en
dc.format.mimetype application/pdf en
dc.language.iso en en
dc.publisher Oxford University Press en
dc.rights © The Author 2017. Published by Oxford University Press on behalf of the Association of Physicians. All rights reserved. This is a pre-copyedited, author-produced version of an article accepted for publication in QJM following peer review. The version of record is available online at: https://doi.org/10.1093/qjmed/hcx091 en
dc.subject Physical activity en
dc.subject Coronary arteriosclerosis en
dc.subject Aerobic exercise en
dc.subject Inflammatory markers en
dc.subject Inflammation en
dc.subject Diabetes mellitus en
dc.subject Type 2 en
dc.subject Exercise en
dc.subject Adult biological markers en
dc.subject Interleukin-8 en
dc.subject Interleukins en
dc.subject C-reactive protein en
dc.subject Interleukin-6 en
dc.subject Exercise en
dc.subject Resistive en
dc.subject Tumor necrosis en
dc.subject Narrative discourse en
dc.subject Strength training en
dc.title The effect of exercise interventions on inflammatory biomarkers in healthy, physically inactive subjects: a systematic review en
dc.type Article (peer-reviewed) en
dc.internal.authorcontactother Fergus Shanahan, Medicine, University College Cork, Ireland. T: +353 21 490 3000, E: f.shanahan@ucc.ie en
dc.internal.availability Full text available en
dc.check.info Access to this article is restricted until 12 months after publication at the request of the publisher. en
dc.check.date 2018-05-02
dc.description.version Accepted Version en
dc.contributor.funder Science Foundation Ireland en
dc.contributor.funder Irish Centre for Arthritis Research and Education (ICARE) en
dc.description.status Peer reviewed en
dc.identifier.journaltitle QJM: An International Journal of Medicine en
dc.internal.IRISemailaddress f.shanahan@ucc.ie en


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