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Semaphorin 6A knockout mice display abnormalities across ethologically-based topographies of exploration and in motor learning
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Accepted Version
Date
2017-01-18
Authors
HÃ¥kansson, Kerstin
Runker, Annette
O'Sullivan, Gerard J.
Mitchell, Kevin J.
Waddington, John L.
O'Tuathaigh, Colm M. P.
Journal Title
Journal ISSN
Volume Title
Publisher
Elsevier Ltd
Published Version
Abstract
Semaphorins are secreted or membrane-bound proteins implicated in neurodevelopmental processes of axon guidance and cell migration. Exploratory behaviour and motor learning was examined ethologically in Semaphorin 6A (Sema6A) mutant mice. The ethogram of initial exploration in Sema6A knockout mice was characterised by increased rearing to wall with decreased sifting; over subsequent habituation, locomotion, sniffing and rearing to wall were increased, with reduced habituation of rearing seated. Rotarod analysis indicated delayed motor learning in Sema6A heterozygous mutants. Disruption to the axonal guidance and cell migration processes regulated by Sema6A is associated with topographically specific disruption to fundamental aspects of behaviour, namely the ethogram of initial exploration and subsequent habituation to the environment, and motor learning.
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Keywords
Semaphorin 6A , Knockout mice , Behavioural phenotype , Ethogram , Motor learning
Citation
HÃ¥kansson, K., Runker, A., O'Sullivan, G. J., Mitchell, K. J., Waddington, J. L. and O'Tuathaigh, C. M. P. (2017) 'Semaphorin 6A knockout mice display abnormalities across ethologically-based topographies of exploration and in motor learning', Neuroscience Letters, 641, pp. 70-76. doi:10.1016/j.neulet.2017.01.043