Access to some C5-cyclised 2 pyrones and 2-pyridones via direct arylation; retention of chloride as a synthetic handle

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Date
2017-08-04
Authors
McGlacken, Gerard P.
Fairlamb, Ian
Prendergast, Aisling
Pardo, Leticia
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John Wiley & Sons, Ltd
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Abstract
The synthetic effort towards the functionalisation of C-H bonds on 2 pyrones and 2-pyridones has been funnelled by the preferential reactivity of the C-3 position. Herein, we report a direct arylation protocol for the intramolecular coupling of 2 pyrones and 2 pyridones, allowing access to a previously unavailable class of C-5 cyclised products with an unstudied biological profile. A C-Cl bond was retained at C-3 during the direct arylation process allowing further derivatisation at C-3, which we have demonstrated with a proof-of-principle Suzuki-Miyaura cross-coupling reaction.
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Keywords
C-H activation , Cross-coupling , Heterocycles , Palladium , Synthetic methods
Citation
McGlacken, G. P., Fairlamb, I., Prendergast, A. and Pardo, L. (2017) 'Access to some C5-cyclised 2 pyrones and 2-pyridones via direct arylation; retention of chloride as a synthetic handle', European Journal of Organic Chemistry, 2017(34), pp. 5119-5124. doi:10.1002/ejoc.201700980
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© 2017, John Wiley & Sons Ltd. This is the peer reviewed version of the following article: McGlacken, G. P., Fairlamb, I., Prendergast, A. and Pardo, L. (2017) 'Access to some C5-cyclised 2 pyrones and 2-pyridones via direct arylation; retention of chloride as a synthetic handle', European Journal of Organic Chemistry, 2017(34), pp. 5119-5124, which has been published in final form at http://dx.doi.org/ 10.1002/ejoc.201700980. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Self-Archiving.