Bacteriocins: antibiotics in the age of the microbiome

Show simple item record Egan, Kevin Ross, R. Paul Hill, Colin 2017-09-14T13:37:48Z 2017-09-14T13:37:48Z 2017-04-07
dc.identifier.citation Egan, K., Ross, R. P. and Hill, C. (2017) 'Bacteriocins: antibiotics in the age of the microbiome', Emerging Topics in Life Sciences, 1(1), pp. 55-63. doi: 10.1042/etls20160015 en
dc.identifier.volume 1 en
dc.identifier.issued 1 en
dc.identifier.startpage 55 en
dc.identifier.endpage 63 en
dc.identifier.issn 2397-8554
dc.identifier.issn 2397-8562
dc.identifier.doi 10.1042/etls20160015
dc.description.abstract Antibiotics have revolutionised the treatment of infectious disease and improved the lives of billions of people worldwide over many decades. With the rise in antimicrobial resistance (AMR) and corresponding lack of antibiotic development, we find ourselves in dire need of alternative treatments. Bacteriocins are a class of bacterially produced, ribosomally synthesised, antimicrobial peptides that may be narrow or broad in their spectra of activity. Animal models have demonstrated the safety and efficacy of bacteriocins in treating a broad range of infections; however, one of the principal drawbacks has been their relatively narrow spectra when compared with small-molecule antibiotics. In an era where we are beginning to appreciate the role of the microbiota in human and animal health, the fact that bacteriocins cause much less collateral damage to the host microbiome makes them a highly desirable therapeutic. This review makes a case for the implementation of bacteriocins as therapeutic antimicrobials, either alone or in combination with existing antibiotics to alleviate the AMR crisis and to lessen the impact of antibiotics on the host microbiome. en
dc.description.sponsorship Department of Agriculture, Food and the Marine (Irish Government under the National Development Plan, through the Food Institutional Research Measure, administered by Department of Agriculture, Fisheries and Food, Ireland (DAFM 13/F/462); Science Foundation Ireland (SFI Investigator awards (10/IN.1/B3027) and the APC Microbiome institute under Grant Number SFI/12/RC/2273) en
dc.format.mimetype application/pdf en
dc.language.iso en en
dc.publisher Portland Press en
dc.rights © 2017 The Authors; published by Portland Press Limited on behalf of the Biochemical Society and the Royal Society of Biology en
dc.subject Antibiotic en
dc.subject Antimicrobial resistance en
dc.subject Bacteriocin en
dc.subject Microbiome en
dc.subject Probiotic en
dc.title Bacteriocins: antibiotics in the age of the microbiome en
dc.type Article (peer-reviewed) en
dc.internal.authorcontactother Kevin Egan, Microbiology, University College Cork, University College Cork, Cork, Ireland. +353-21-490-3000 en
dc.internal.availability Full text available en Access to this article is restricted until 12 months after publication by request of the publisher en 2018-04-07
dc.description.version Accepted Version en
dc.contributor.funder Department of Agriculture, Food and the Marine en
dc.contributor.funder Science Foundation Ireland en
dc.description.status Peer reviewed en
dc.identifier.journaltitle Emerging Topics in Life Sciences en
dc.internal.copyrightchecked !!CORA!! en

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