Gold nanoparticles enlighten the future of cancer theranostics

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dc.contributor.author Guo, Jianfeng
dc.contributor.author Rahme, Kamil
dc.contributor.author He, Yan
dc.contributor.author Li, Lin-Lin
dc.contributor.author Holmes, Justin D.
dc.contributor.author O'Driscoll, Caitríona M.
dc.date.accessioned 2017-09-20T15:43:11Z
dc.date.available 2017-09-20T15:43:11Z
dc.date.issued 2017-08
dc.identifier.citation Guo, J., Rahme, K., He, Y., Li, L., Ho,lmes, J. D. and O'Driscoll, C. M. (2017) 'Gold nanoparticles enlighten the future of cancer theranostics'. International Journal of Nanomedicine, 12, pp. 6131-6152. doi: 10.2147/IJN.S140772 en
dc.identifier.volume 12 en
dc.identifier.startpage 6131 en
dc.identifier.endpage 6152 en
dc.identifier.issn 1178-2013
dc.identifier.uri http://hdl.handle.net/10468/4753
dc.identifier.doi 10.2147/IJN.S140772
dc.description.abstract Development of multifunctional nanomaterials, one of the most interesting and advanced research areas in the field of nanotechnology, is anticipated to revolutionize cancer diagnosis and treatment. Gold nanoparticles (AuNPs) are now being widely utilized in bioimaging and phototherapy due to their tunable and highly sensitive optical and electronic properties (the surface plasmon resonance). As a new concept, termed “theranostics,” multifunctional AuNPs may contain diagnostic and therapeutic functions that can be integrated into one system, thereby simultaneously facilitating diagnosis and therapy and monitoring therapeutic responses. In this review, the important properties of AuNPs relevant to diagnostic and phototherapeutic applications such as structure, shape, optics, and surface chemistry are described. Barriers for translational development of theranostic AuNPs and recent advances in the application of AuNPs for cancer diagnosis, photothermal, and photodynamic therapy are discussed. en
dc.description.sponsorship People's Government of Jilin Province (Department of Science and Technology, Jilin Province (Outstanding Youth Foundation, Project Number: 20170520046JH)); Jilin University (Start-Up Research Grant Program (Project Number: 451160102052)); Haematology Association of Ireland and Novartis Oncology (HAI-Novartis Fellowship Award); Conseil National de la Recherche Scientifique, National Council for Scientific Research Lebanon (CNRS Lebanon GRP2015) en
dc.format.mimetype application/pdf en
dc.language.iso en en
dc.publisher Dove Medical Press en
dc.rights © 2017 Guo et al. This work is published and licensed by Dove Medical Press Limited. The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution - Non Commercial (unported, v3.0) License. By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. For permission for commercial use of this work, please see paragraphs 4.2 and 5 of our Terms. en
dc.rights.uri https://creativecommons.org/licenses/by-nc/3.0/ en
dc.subject Multifunctional gold nanoparticles en
dc.subject Cancer bioimaging en
dc.subject Cancer photothermal and photodynamic therapy en
dc.subject Near-infrared light en
dc.subject Scattering submicroscopic particles en
dc.subject Enhanced photothermal therapy en
dc.subject Highly fluorescent analogs en
dc.subject Surface-plasmon resonance en
dc.subject Nucleic-acid delivery en
dc.subject In-vivo en
dc.subject Photodynamic therapy en
dc.subject Optical-properties en
dc.subject Sirna delivery en
dc.title Gold nanoparticles enlighten the future of cancer theranostics en
dc.type Article (peer-reviewed) en
dc.internal.authorcontactother Justin D. Holmes, Chemistry, University College Cork, Cork, Ireland. +353-21-490-3000 Email: j.holmes@ucc.ie en
dc.internal.availability Full text available en
dc.date.updated 2017-09-20T15:25:48Z
dc.description.version Published Version en
dc.internal.rssid 411793313
dc.internal.wokid WOS:000408096000002
dc.contributor.funder People's Government of Jilin Province en
dc.contributor.funder Jilin University en
dc.contributor.funder Conseil National de la Recherche Scientifique en
dc.contributor.funder Novartis en
dc.contributor.funder Haematology Association of Ireland en
dc.description.status Peer reviewed en
dc.identifier.journaltitle International Journal of Nanomedicine en
dc.internal.copyrightchecked No !!CORA!! en
dc.internal.licenseacceptance Yes en
dc.internal.IRISemailaddress j.holmes@ucc.ie en


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© 2017 Guo et al. This work is published and licensed by Dove Medical Press Limited. The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution - Non Commercial (unported, v3.0) License. By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. For permission for commercial use of this work, please see paragraphs 4.2 and 5 of our Terms. Except where otherwise noted, this item's license is described as © 2017 Guo et al. This work is published and licensed by Dove Medical Press Limited. The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution - Non Commercial (unported, v3.0) License. By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. For permission for commercial use of this work, please see paragraphs 4.2 and 5 of our Terms.
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