The impact of western diet and nutrients on the microbiota and immune response at mucosal interfaces

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dc.contributor.author Statovci, Donjete
dc.contributor.author Aguilera, Monica
dc.contributor.author MacSharry, John
dc.contributor.author Melgar, Silvia
dc.date.accessioned 2017-09-26T11:39:20Z
dc.date.available 2017-09-26T11:39:20Z
dc.date.issued 2017
dc.identifier.citation Statovci, D., Aguilera, M., MacSharry, J. and Melgar, S. (2017) 'The impact of western diet and nutrients on the microbiota and immune response at mucosal interfaces', Frontiers in Immunology, 8, 838 (21pp). doi: 10.3389/fimmu.2017.00838 en
dc.identifier.volume 8
dc.identifier.issn 1664-3224
dc.identifier.uri http://hdl.handle.net/10468/4797
dc.identifier.doi 10.3389/fimmu.2017.00838
dc.description.abstract Recent findings point toward diet having a major impact on human health. Diets can either affect the gut microbiota resulting in alterations in the host's physiological responses or by directly targeting the host response. The microbial community in the mammalian gut is a complex and dynamic system crucial for the development and maturation of both systemic and mucosal immune responses. Therefore, the complex interaction between available nutrients, the microbiota, and the immune system are central regulators in maintaining homeostasis and fighting against invading pathogens at mucosal sites. Westernized diet, defined as high dietary intake of saturated fats and sucrose and low intake of fiber, represent a growing health risk contributing to the increased occurrence of metabolic diseases, e.g., diabetes and obesity in countries adapting a westernized lifestyle. Inflammatory bowel diseases (IBD) and asthma are chronic mucosal inflammatory conditions of unknown etiology with increasing prevalence worldwide. These conditions have a multifactorial etiology including genetic factors, environmental factors, and dysregulated immune responses. Their increased prevalence cannot solely be attributed to genetic considerations implying that other factors such as diet can be a major contributor. Recent reports indicate that the gut microbiota and modifications thereof, due to a consumption of a diet high in saturated fats and low in fibers, can trigger factors regulating the development and/or progression of both conditions. While asthma is a disease of the airways, increasing evidence indicates a link between the gut and airways in disease development. Herein, we provide a comprehensive review on the impact of westernized diet and associated nutrients on immune cell responses and the microbiota and how these can influence the pathology of IBD and asthma. en
dc.format.mimetype application/pdf en
dc.language.iso en en
dc.publisher Frontiers Media S.A. en
dc.relation.uri http://journal.frontiersin.org/article/10.3389/fimmu.2017.00838/full
dc.rights © 2017, Statovci, Aguilera, MacSharry and Melgar. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. en
dc.rights.uri https://creativecommons.org/licenses/by/4.0/
dc.subject Westernized diet en
dc.subject Inflammatory bowel disease en
dc.subject Asthma en
dc.subject Saturated fat en
dc.subject Micronutrients en
dc.subject Microbiota en
dc.subject Inflammatory bowel disease en
dc.subject Polyunsaturated fatty acids en
dc.subject Innate lymphoid cells en
dc.subject Vitamin D receptor en
dc.subject Mesenteric adipose tissue en
dc.subject Sodium induced colitis en
dc.subject Piama birth cohort en
dc.subject Regulatory t cells en
dc.subject Crohns disease en
dc.subject Ulcerative colitis en
dc.title The impact of western diet and nutrients on the microbiota and immune response at mucosal interfaces en
dc.type Article (peer-reviewed) en
dc.internal.authorcontactother John MacSharry, Alimentary Pharmabiotic Centre, University College Cork, Cork, Ireland. +353-21-490-3000 Email: j.macsharry@ucc.i en
dc.internal.availability Full text available en
dc.description.version Published Version en
dc.internal.wokid WOS:000406476000001
dc.contributor.funder Science Foundation Ireland
dc.description.status Peer reviewed en
dc.identifier.journaltitle Frontiers in Immunology en
dc.internal.IRISemailaddress j.macsharry@ucc.ie en
dc.identifier.articleid 838
dc.relation.project info:eu-repo/grantAgreement/SFI/SFI Research Centres/12/RC/2273/IE/Alimentary Pharmabiotic Centre (APC) - Interfacing Food & Medicine/


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© 2017, Statovci, Aguilera, MacSharry and Melgar. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. Except where otherwise noted, this item's license is described as © 2017, Statovci, Aguilera, MacSharry and Melgar. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
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