Ethnic differences in the prevalence of inherited thrombophilic polymorphisms in an asymptomatic Australian prenatal population

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dc.contributor.author Said, Joanne M.
dc.contributor.author Brennecke, Shaun P.
dc.contributor.author Moses, Eric K.
dc.contributor.author Walker, Susan P.
dc.contributor.author Borg, Anthony J.
dc.contributor.author Williams, Jeff T.
dc.contributor.author Higgins, John R.
dc.date.accessioned 2011-12-19T11:37:18Z
dc.date.available 2011-12-19T11:37:18Z
dc.date.copyright 2006
dc.date.issued 2006-08
dc.identifier.citation Said JM; Brennecke SP; Moses EK; Walker SP; Borg AJ; Williams JT; Higgins JR; (2006) 'Ethnic differences in the prevalence of inherited thrombophilic polymorphisms in an asymptomatic Australian prenatal population'. Human biology; an international record of research, 78 (4):403-412. en
dc.identifier.volume 78 en
dc.identifier.issued 4 en
dc.identifier.startpage 403 en
dc.identifier.endpage 412 en
dc.identifier.issn 1534-6617
dc.identifier.issn 0018-7143
dc.identifier.uri http://hdl.handle.net/10468/480
dc.identifier.doi 10.1353/hub.2006.0058
dc.description.abstract Differences in the prevalence of thrombophilias in different ethnic populations have been demonstrated. Because the Australian population includes many different ethnic groups, we sought to assess the effect of ethnicity in our Australian prenatal population on the prevalence of thrombophilic polymorphisms. Asymptomatic, nulliparous women (n = 1,129) recruited for a large prospective study were included in this analysis. These women had no personal or family history of venous thromboembolism and were not known to be carrying an inherited or acquired thrombophilia. Ethnicity was determined at recruitment, and women were categorized as being of Northern European, Southern European, Middle Eastern, Asian, or Other ethnicity. These women underwent genotyping for the following polymorphisms: factor V Leiden G1691A, prothrombin gene A20210G mutation, methylenetetrahydrofolate reductase (MTHFR) C677T and A1298C, and thrombomodulin C1418T. The factor V Leiden allele was seen significantly more frequently in patients of Middle Eastern background compared to those of Northern European and Asian ethnicity (p < 0.05). The prothrombin gene mutation was seen significantly more frequently in patients of Southern European ethnicity compared to those of Northern European or Asian ethnicity (p < 0.05). The MTHFR C677T allele (mutant) was significantly less common in those of Asian ethnicity compared to patients of Northern European and Southern European ethnicity (p < 0.0005). There were no significant differences seen with the MTHFR A1298C polymorphism. The mutant thrombomodulin allele was seen significantly more frequently in Asian women compared to Northern European, Southern European, or Middle Eastern women (p < 0.005). There are important ethnic differences in the prevalence of thrombophilic polymorphisms in the Australian prenatal population. en
dc.description.sponsorship Kings Jubilee Fund (City of Melbourne); the Royal Womens Hospital; University of Melbourne (Australian Postgraduate Award and Felix Meyer Scholarship) en
dc.format.mimetype application/pdf en
dc.language.iso en en
dc.publisher The Wayne State University Press en
dc.relation.uri http://muse.jhu.edu/journals/human_biology/v078/78.4said.html
dc.rights Copyright © 2006 by The Wayne State University Press. All rights reserved. en
dc.subject Thrombophilia en
dc.subject Factor V Leiden en
dc.subject Prothrombin gene en
dc.subject Methylenetetrahydrofolate reductase (MTHFR) en
dc.subject Thrombomodulin en
dc.subject Australia en
dc.subject Prenatal population en
dc.subject.lcsh Thromboembolism en
dc.subject.lcsh Pregnancy en
dc.title Ethnic differences in the prevalence of inherited thrombophilic polymorphisms in an asymptomatic Australian prenatal population en
dc.type Article (peer-reviewed) en
dc.internal.authorurl http://publish.ucc.ie/researchprofiles/C001/jhiggins en
dc.internal.authorcontactother John Higgins, College Of Medicine & Health Office, University College Cork, Cork, Ireland. +353-21-490-3000 Email: j.higgins@ucc.ie en
dc.internal.availability Full text available en
dc.date.updated 2011-12-19T09:57:02Z
dc.description.version Published Version en
dc.internal.rssid 69093571
dc.internal.pmid 17278618
dc.description.status Peer reviewed en
dc.identifier.journaltitle Human biology en
dc.internal.copyrightchecked Yes RoMEO. 0018-7143, ESSN: 1534-6617.Copyright © 2006 by The Wayne State University Press. All rights reserved. en
dc.internal.licenseacceptance Yes en
dc.internal.IRISemailaddress j.higgins@ucc.ie en


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