Prediction of delivering a small for gestational age infant and adverse perinatal outcome in women with suspected pre-eclampsia

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dc.contributor.author Griffin, Melanie
dc.contributor.author Seed, Paul T.
dc.contributor.author Duckworth, Suzy
dc.contributor.author North, Robyn
dc.contributor.author Myers, Jenny
dc.contributor.author Mackillop, Lucy
dc.contributor.author Simpson, Nigel
dc.contributor.author Waugh, Jason
dc.contributor.author Anumba, Dilly
dc.contributor.author Kenny, Louise C.
dc.contributor.author Redman, Christopher W. G.
dc.contributor.author Shennan, Andrew H.
dc.contributor.author Chappell, Lucy C.
dc.date.accessioned 2017-10-10T11:30:59Z
dc.date.available 2017-10-10T11:30:59Z
dc.date.issued 2017-04-12
dc.identifier.citation Griffin, M., Seed, P. T., Duckworth, S., North, R., Myers, J., Mackillop, L., Simpson, N., Waugh, J., Anumba, D., Kenny, L. C., Redman, C. W. G., Shennan, A. H. and Chappell, L. C. (2017) 'Prediction of delivering a small for gestational age infant and adverse perinatal outcome in women with suspected pre-eclampsia', Ultrasound in Obstetrics & Gynecology, In Press. doi:10.1002/uog.17490 en
dc.identifier.issn 1469-0705
dc.identifier.uri http://hdl.handle.net/10468/4853
dc.identifier.doi 10.1002/uog.17490
dc.description.abstract Objective: To evaluate the test performance of 47 biomarkers and ultrasound parameters to predict subsequent delivery of an SGA infant and adverse perinatal outcome in women presenting with suspected preeclampsia. Methods: In a prospective, multicentre observational study, 47 biomarkers and ultrasound parameters were measured in 397 women presenting with suspected preterm preeclampsia, with the objective of evaluating them as predictors of subsequent delivery of an SGA infant and adverse perinatal outcome. Factor analysis and stepwise logistic regression were performed in two pre-specified groups. Results: In 274 women presenting at 20+0 to 34+6 weeks’ gestation (Group 1), 96 (35%) delivered an SGA infant <3rd customised birthweight centile (SGA-3). For prediction of SGA-3, low maternal Placental Growth Factor (PlGF) concentrations had a sensitivity of 93% (95%CI 84% to 98%) and negative predictive value (NPV) of 90% (95%CI 76% to 97%) compared to a sensitivity of 71% (95%CI 58% to 82%) and a NPV of 79% (95%CI 68% to 87%) for ultrasound parameters (estimated fetal weight or abdominal circumference <10th centile). No individual biomarker evaluated had superior performance to PlGF and combinations added only small increments to test performance. Similar results were found in 123 women presenting between 35+0 to 36+6 weeks’ gestation (Group 2). Conclusions: In women presenting with suspected preterm preeclampsia, measurement of PlGF offers a useful adjunct for identifying those at high risk of delivering an SGA infant, allowing appropriate surveillance and timely intervention. en
dc.format.mimetype application/pdf en
dc.language.iso en en
dc.publisher Wiley en
dc.rights © 2017 The Authors. Ultrasound in Obstetrics & Gynecology published by John Wiley & Sons Ltd on behalf of the International Society of Ultrasound in Obstetrics and Gynecology. This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited. en
dc.rights.uri https://creativecommons.org/licenses/by/4.0/ en
dc.subject Small-for-gestational age en
dc.subject Pre-eclampsia en
dc.subject Growth restriction en
dc.subject Placental growth factor en
dc.title Prediction of delivering a small for gestational age infant and adverse perinatal outcome in women with suspected pre-eclampsia en
dc.type Article (peer-reviewed) en
dc.internal.authorcontactother Louise Kenny, Obstetrics & Gynaecology, University College Cork, Cork, Ireland. +353-21-490-3000 Email: l.kenny@ucc.ie en
dc.internal.availability Full text available en
dc.date.updated 2017-06-16T14:39:33Z
dc.description.version Accepted Version en
dc.internal.rssid 399323482
dc.contributor.funder Tommy's Baby Charity en
dc.contributor.funder National Institute for Health Research en
dc.contributor.funder Guy's and St Thomas' NHS Foundation Trust en
dc.contributor.funder Kings College London en
dc.contributor.funder Science Foundation Ireland en
dc.contributor.funder Action Medical Research en
dc.description.status Peer reviewed en
dc.identifier.journaltitle Ultrasound In Obstetrics & Gynecology en
dc.internal.copyrightchecked No !!CORA!! en
dc.internal.licenseacceptance Yes en
dc.internal.IRISemailaddress l.kenny@ucc.ie en
dc.relation.project info:eu-repo/grantAgreement/SFI/SFI Research Centres/12/RC/2272/IE/Irish Centre for Fetal and Neonatal Translational Research (INFANT)/


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© 2017 The Authors. Ultrasound in Obstetrics & Gynecology published by John Wiley & Sons Ltd on behalf of the International Society of Ultrasound in Obstetrics and Gynecology. This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited. Except where otherwise noted, this item's license is described as © 2017 The Authors. Ultrasound in Obstetrics & Gynecology published by John Wiley & Sons Ltd on behalf of the International Society of Ultrasound in Obstetrics and Gynecology. This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
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