Current status and future prospects of marine natural products (MNPs) as antimicrobials

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dc.contributor.author Choudhary, Alka
dc.contributor.author Naughton, Lynn
dc.contributor.author Montánchez, Itxaso
dc.contributor.author Dobson, Alan D. W.
dc.contributor.author Rai, Dilip K.
dc.date.accessioned 2017-10-18T09:40:14Z
dc.date.available 2017-10-18T09:40:14Z
dc.date.issued 2017
dc.identifier.citation Choudhary, A., Naughton, L., Montánchez, I., Dobson, A. and Rai, D. (2017) 'Current status and future prospects of marine natural products (MNPs) as antimicrobials', Marine Drugs, 15(9), 272 (42pp). doi: 10.3390/md15090272 en
dc.identifier.volume 15
dc.identifier.issued 9
dc.identifier.startpage 1
dc.identifier.endpage 42
dc.identifier.issn 1660-3397
dc.identifier.uri http://hdl.handle.net/10468/4891
dc.identifier.doi 10.3390/md15090272
dc.description.abstract The marine environment is a rich source of chemically diverse, biologically active natural products, and serves as an invaluable resource in the ongoing search for novel antimicrobial compounds. Recent advances in extraction and isolation techniques, and in state-of-the-art technologies involved in organic synthesis and chemical structure elucidation, have accelerated the numbers of antimicrobial molecules originating from the ocean moving into clinical trials. The chemical diversity associated with these marine-derived molecules is immense, varying from simple linear peptides and fatty acids to complex alkaloids, terpenes and polyketides, etc. Such an array of structurally distinct molecules performs functionally diverse biological activities against many pathogenic bacteria and fungi, making marine-derived natural products valuable commodities, particularly in the current age of antimicrobial resistance. In this review, we have highlighted several marine-derived natural products (and their synthetic derivatives), which have gained recognition as effective antimicrobial agents over the past five years (2012–2017). These natural products have been categorized based on their chemical structures and the structure-activity mediated relationships of some of these bioactive molecules have been discussed. Finally, we have provided an insight into how genome mining efforts are likely to expedite the discovery of novel antimicrobial compounds. en
dc.description.sponsorship Department of Agriculture, Food and the Marine (food institutional Research Measure (FIRM 11/F/009) en
dc.format.mimetype application/pdf en
dc.language.iso en en
dc.publisher MDPI en
dc.relation.uri http://www.mdpi.com/1660-3397/15/9/272
dc.rights © 2017, the Authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/) en
dc.rights.uri https://creativecommons.org/licenses/by/4.0/
dc.subject Antimicrobial en
dc.subject Marine natural products (MNPs) en
dc.subject Secondary metabolites en
dc.subject Antibacterial en
dc.subject Antifungal en
dc.subject Genome mining en
dc.title Current status and future prospects of marine natural products (MNPs) as antimicrobials en
dc.type Article (peer-reviewed) en
dc.internal.authorcontactother Alan Dobson, Microbiology, University College Cork, Cork, Ireland. +353-21-490-3000 Email: a.dobson@ucc.ie en
dc.internal.availability Full text available en
dc.description.version Published Version en
dc.contributor.funder Department of Agriculture, Food and the Marine
dc.description.status Peer reviewed en
dc.identifier.journaltitle Marine Drugs en
dc.internal.IRISemailaddress a.dobson@ucc.ie en
dc.identifier.articleid 272


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© 2017, the Authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/) Except where otherwise noted, this item's license is described as © 2017, the Authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/)
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