Cross talk: the microbiota and neurodevelopmental disorders

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dc.contributor.author Kelly, John R.
dc.contributor.author Minuto, Chiara
dc.contributor.author Cryan, John F.
dc.contributor.author Clarke, Gerard
dc.contributor.author Dinan, Timothy G.
dc.date.accessioned 2017-10-18T09:40:15Z
dc.date.available 2017-10-18T09:40:15Z
dc.date.issued 2017
dc.identifier.citation Kelly, J. R., Minuto, C., Cryan, J. F., Clarke, G. and Dinan, T. G. (2017) 'Cross talk: the microbiota and neurodevelopmental disorders', Frontiers in Neuroscience, 11, 490 (31pp). doi: 10.3389/fnins.2017.00490 en
dc.identifier.volume 11
dc.identifier.startpage 1
dc.identifier.endpage 31
dc.identifier.issn 1662-4548
dc.identifier.issn 1662-453X
dc.identifier.uri http://hdl.handle.net/10468/4899
dc.identifier.doi 10.3389/fnins.2017.00490
dc.description.abstract Humans evolved within a microbial ecosystem resulting in an interlinked physiology. The gut microbiota can signal to the brain via the immune system, the vagus nerve or other host-microbe interactions facilitated by gut hormones, regulation of tryptophan metabolism and microbial metabolites such as short chain fatty acids (SCFA), to influence brain development, function and behavior. Emerging evidence suggests that the gut microbiota may play a role in shaping cognitive networks encompassing emotional and social domains in neurodevelopmental disorders. Drawing upon pre-clinical and clinical evidence, we review the potential role of the gut microbiota in the origins and development of social and emotional domains related to Autism spectrum disorders (ASD) and schizophrenia. Small preliminary clinical studies have demonstrated gut microbiota alterations in both ASD and schizophrenia compared to healthy controls. However, we await the further development of mechanistic insights, together with large scale longitudinal clinical trials, that encompass a systems level dimensional approach, to investigate whether promising pre-clinical and initial clinical findings lead to clinical relevance. en
dc.description.sponsorship Health Research Board (HRA_POR/2011/23; HRA_POR/2012/32; HRA-POR-2-14-647); Brain and Behavior Research Foundation (Grant Number 20771 NARSAD Young Investigator Grant). en
dc.format.mimetype application/pdf en
dc.language.iso en en
dc.publisher Frontiers Media en
dc.relation.uri https://www.frontiersin.org/articles/10.3389/fnins.2017.00490/full
dc.rights © 2017, Kelly, Minuto, Cryan, Clarke and Dinan. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms en
dc.rights.uri https://creativecommons.org/licenses/by/4.0/
dc.subject Microbiota en
dc.subject Microbiome en
dc.subject Gut-brain axis en
dc.subject Immune system en
dc.subject Social cognition en
dc.subject Autism en
dc.subject Schizophrenia en
dc.subject Psychobiotics en
dc.title Cross talk: the microbiota and neurodevelopmental disorders en
dc.type Article (peer-reviewed) en
dc.internal.authorcontactother Ted Dinan, Psychiatry, University College Cork, Cork, Ireland. +353-21-490-3000 Email: t.dinan@ucc.ie en
dc.internal.availability Full text available en
dc.description.version Published Version en
dc.contributor.funder Brain and Behavior Research Foundation
dc.contributor.funder Seventh Framework Programme
dc.contributor.funder Health Research Board
dc.contributor.funder Science Foundation Ireland
dc.description.status Peer reviewed en
dc.identifier.journaltitle Frontiers in Neuroscience en
dc.internal.IRISemailaddress t.dinan@ucc.ie en
dc.identifier.articleid 490
dc.relation.project info:eu-repo/grantAgreement/EC/FP7::SP1::KBBE/613979/EU/Microbiome Influence on Energy balance and Brain Development-Function Put into Action to Tackle Diet-related Diseases and Behavior./MYNEWGUT
dc.relation.project info:eu-repo/grantAgreement/SFI/SFI Research Centres/12/RC/2273/IE/Alimentary Pharmabiotic Centre (APC) - Interfacing Food & Medicine/


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© 2017, Kelly, Minuto, Cryan, Clarke and Dinan. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms Except where otherwise noted, this item's license is described as © 2017, Kelly, Minuto, Cryan, Clarke and Dinan. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms
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