Sphingosine 1-phosphate (S1P) signalling: role in bone biology and potential therapeutic target for bone repair

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dc.contributor.author Sartawi, Ziad
dc.contributor.author Schipani, Ernestina
dc.contributor.author Ryan, Katie B.
dc.contributor.author Waeber, Christian
dc.date.accessioned 2017-10-20T11:06:49Z
dc.date.available 2017-10-20T11:06:49Z
dc.date.issued 2017-08-30
dc.identifier.citation Sartawi, Z., Schipani, E., Ryan, K. B. and Waeber, C. (2017) 'Sphingosine 1-phosphate (S1P) signalling: role in bone biology and potential therapeutic target for bone repair', Pharmacological Research, 125, pp. 232-245. doi:10.1016/j.phrs.2017.08.013 en
dc.identifier.volume 125 en
dc.identifier.startpage 232 en
dc.identifier.endpage 245 en
dc.identifier.issn 1043-6618
dc.identifier.uri http://hdl.handle.net/10468/4922
dc.identifier.doi 10.1016/j.phrs.2017.08.013
dc.description.abstract The lipid mediator sphingosine 1-phosphate (S1P) affects cellular functions in most systems. Interest in its therapeutic potential has increased following the discovery of its G protein-coupled receptors and the recent availability of agents that can be safely administered in humans. Although the role of S1P in bone biology has been the focus of much less research than its role in the nervous, cardiovascular and immune systems, it is becoming clear that this lipid influences many of the functions, pathways and cell types that play a key role in bone maintenance and repair. Indeed, S1P is implicated in many osteogenesis-related processes including stem cell recruitment and subsequent differentiation, differentiation and survival of osteoblasts, and coupling of the latter cell type with osteoclasts. In addition, S1P’s role in promoting angiogenesis is well-established. The pleiotropic effects of S1P on bone and blood vessels have significant potential therapeutic implications, as current therapeutic approaches for critical bone defects show significant limitations. Because of the complex effects of S1P on bone, the pharmacology of S1P-like agents and their physico-chemical properties, it is likely that therapeutic delivery of S1P agents will offer significant advantages compared to larger molecular weight factors. Hence, it is important to explore novel methods of utilizing S1P agents therapeutically, and improve our understanding of how S1P and its receptors modulate bone physiology and repair. en
dc.format.mimetype application/pdf en
dc.language.iso en en
dc.publisher Elsevier Ltd en
dc.rights © 2017, Elsevier Ltd. All rights reserved. This manuscript version is made available under the CC-BY-NC-ND 4.0 license. en
dc.rights.uri http://creativecommons.org/licenses/by-nc-nd/4.0/ en
dc.subject Bone regeneration en
dc.subject Bone defect en
dc.subject Osteoblasts en
dc.subject Osteoclasts en
dc.subject Sphingosine 1-phosphate en
dc.title Sphingosine 1-phosphate (S1P) signalling: role in bone biology and potential therapeutic target for bone repair en
dc.type Article (peer-reviewed) en
dc.internal.authorcontactother Katie Ryan, School Of Pharmacy, University College Cork, Cork, Ireland. +353-21-490-3000 Email: katie.ryan@ucc.ie en
dc.internal.availability Full text available en
dc.check.info Access to this article is restricted until 12 months after publication by request of the publisher. en
dc.check.date 2018-08-30
dc.date.updated 2017-09-22T12:18:53Z
dc.description.version Accepted Version en
dc.internal.rssid 412048158
dc.description.status Peer reviewed en
dc.identifier.journaltitle Pharmacological Research en
dc.internal.copyrightchecked Yes en
dc.internal.licenseacceptance Yes en
dc.internal.IRISemailaddress katie.ryan@ucc.ie en


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© 2017, Elsevier Ltd. All rights reserved. This manuscript version is made available under the CC-BY-NC-ND 4.0 license. Except where otherwise noted, this item's license is described as © 2017, Elsevier Ltd. All rights reserved. This manuscript version is made available under the CC-BY-NC-ND 4.0 license.
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