Impurity occurrence and removal in crystalline products from process reactions

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dc.contributor.author Moynihan, Humphrey A.
dc.contributor.author Horgan, Danielle E.
dc.date.accessioned 2017-11-10T11:42:03Z
dc.date.available 2017-11-10T11:42:03Z
dc.date.issued 2017-04-10
dc.identifier.citation Moynihan, H. A. and Horgan, D. E. (2017) 'Impurity occurrence and removal in crystalline products from process reactions', Organic Process Research and Development, 21(5), pp. 689-704. doi:10.1021/acs.oprd.6b00403 en
dc.identifier.volume 21 en
dc.identifier.issued 5 en
dc.identifier.startpage 689 en
dc.identifier.endpage 704 en
dc.identifier.issn 1083-6160
dc.identifier.uri http://hdl.handle.net/10468/5006
dc.identifier.doi 10.1021/acs.oprd.6b00403
dc.description.abstract The behavior of impurities when subjected to crystallizations, and related processes such as recrystallization and reslurrying, has been reviewed with a particular focus on the years 2000–2015, but also including significant cases from outside that period. Small molecule pharmaceuticals and similar small organic molecules are included but not biomolecules, inorganics, or minerals. Phase impurities are only covered when a phase transformation is involved with the management of an impurity. Introductory examples illustrating some general features of crystallization as a method of purification are presented, as well as approaches to quantifying the effectiveness of purification. The review classifies cases based on the behavior of the specific impurities covered. The classes of behavior observed are the removal by washing, recrystallization, or reslurrying (Class I), impurities not being removed by these operations (Class II), and impurities which are removed in conjunction with a phase transformation (Class III). Examples of each of these types of behavior are presented, with many processes producing impurities which fall into more than one of these classes. Studies on the inclusion of extraneous molecules into crystalline materials are also covered. These particularly include the incorporation of compounds as solid solutions, but also eutectic formation and inclusion at surfaces during crystal growth. The relationship between types of impurities and behavior during processing is also examined. en
dc.description.sponsorship Irish Research Council (IRSCET-Clarochem-2010-02); University College Cork (2013 Strategic Research Fund); Science Foundation Ireland (Grant Number 05/PICA/B802/EC07) en
dc.format.mimetype application/pdf en
dc.language.iso en en
dc.publisher American Chemical Society en
dc.rights © 2017, American Chemical Society. All rights reserved. This document is the Accepted Manuscript version of a Published Work that appeared in final form in Organic Process Research and Development, after peer review and technical editing by the publisher. To access the final edited and published work see http://pubs.acs.org/doi/abs/10.1021/acs.oprd.6b00403 en
dc.subject Pharmaceuticals en
dc.subject Impurities en
dc.subject Crystallisation en
dc.subject Solid solutions en
dc.title Impurity occurrence and removal in crystalline products from process reactions en
dc.type Article (peer-reviewed) en
dc.internal.authorcontactother Humphrey Moynihan, Chemistry, University College Cork, Cork, Ireland. +353-21-490-3000 Email: h.moynihan@ucc.ie en
dc.internal.availability Full text available en
dc.check.info Access to this article is restricted until 12 months after publication by request of the publisher. en
dc.check.date 2018-04-10
dc.date.updated 2017-11-06T09:38:08Z
dc.description.version Accepted Version en
dc.internal.rssid 391944410
dc.contributor.funder Irish Research Council en
dc.contributor.funder Science Foundation Ireland en
dc.contributor.funder University College Cork en
dc.contributor.funder Clarochem Ireland Ltd
dc.description.status Peer reviewed en
dc.identifier.journaltitle Organic Process Research and Development en
dc.internal.copyrightchecked Yes en
dc.internal.licenseacceptance Yes en
dc.internal.IRISemailaddress h.moynihan@ucc.ie en
dc.relation.project info:eu-repo/grantAgreement/SFI/SFI Strategic Research Cluster/07/SRC/B1158/IE/SRC SSPS: Solid State Pharmaceuticals Cluster (SSPC)/ en
dc.relation.project info:eu-repo/grantAgreement/SFI/SFI Research Centres/12/RC/2275/IE/Synthesis and Solid State Pharmaceutical Centre (SSPC)/ en


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