A profusion of upstream open reading frame mechanisms in polyamine-responsive translational regulation

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dc.contributor.author Ivanov, Ivaylo P.
dc.contributor.author Atkins, John F.
dc.contributor.author Michael, Antony J.
dc.date.accessioned 2017-11-14T13:24:31Z
dc.date.available 2017-11-14T13:24:31Z
dc.date.issued 2010
dc.identifier.citation Ivanov, I. P., Atkins, J. F. and Michael, A. J. (2010) 'A profusion of upstream open reading frame mechanisms in polyamine-responsive translational regulation', Nucleic Acids Research, 38(2), pp. 353-359. doi: 10.1093/nar/gkp1037 en
dc.identifier.volume 38
dc.identifier.issued 2
dc.identifier.startpage 353
dc.identifier.endpage 359
dc.identifier.issn 0305-1048
dc.identifier.uri http://hdl.handle.net/10468/5028
dc.identifier.doi 10.1093/nar/gkp1037
dc.description.abstract In many eukaryotic mRNAs one or more short 'upstream' open reading frames, uORFs, precede the initiator of the main coding sequence. Upstream ORFs are functionally diverse as illustrated by their variety of features in polyamine pathway biosynthetic mRNAs. Their propensity to act as sensors for regulatory circuits and to amplify the signals likely explains their occurrence in most polyamine pathway mRNAs. The uORF-mediated polyamine responsive autoregulatory circuits found in polyamine pathway mRNAs exemplify the translationally regulated dynamic interface between components of the proteome and metabolism. en
dc.description.sponsorship National Institute of Health (R01 GM079523); Biotechnology and Biological Sciences Research Council (Institute Development Fellowship (BB/E024467/1) en
dc.format.mimetype application/pdf en
dc.language.iso en en
dc.publisher Oxford University Press en
dc.relation.uri https://academic.oup.com/nar/article-lookup/doi/10.1093/nar/gkp1037
dc.rights © 2009, the Authors. Published by Oxford University Press. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by-nc/2.5/uk/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited. en
dc.rights.uri http://creativecommons.org/licenses/by-nc/2.5/uk/
dc.subject S-adenosylmethionine decarboxylase en
dc.subject Ornithine decarboxylase en
dc.subject Messenger RNA en
dc.subject Antizyme en
dc.subject Expression en
dc.subject Binding en
dc.subject Protein en
dc.subject Termination en
dc.subject Elongation en
dc.subject Initiation en
dc.title A profusion of upstream open reading frame mechanisms in polyamine-responsive translational regulation en
dc.type Article (peer-reviewed) en
dc.internal.authorcontactother John F. Atkins, Biochemistry, University College Cork , Cork, Ireland T: +353-21-490-3000. E: j.atkins@ucc.ie en
dc.internal.availability Full text available en
dc.description.version Published Version en
dc.contributor.funder Biotechnology and Biological Sciences Research Council
dc.contributor.funder Science Foundation Ireland
dc.contributor.funder National Institutes of Health
dc.description.status Peer reviewed en
dc.identifier.journaltitle Nucleic Acids Research en
dc.internal.IRISemailaddress j.atkins@ucc.ie en


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© 2009, the Authors. Published by Oxford University Press. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by-nc/2.5/uk/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited. Except where otherwise noted, this item's license is described as © 2009, the Authors. Published by Oxford University Press. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by-nc/2.5/uk/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.
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