The CLUSTAL_X windows interface: flexible strategies for multiple sequence alignment aided by quality analysis tools

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dc.contributor.author Thompson, Julie D.
dc.contributor.author Gibson, Tobi J.
dc.contributor.author Plewniak, Frederica
dc.contributor.author Jeanmougin, Francois
dc.contributor.author Higgins, Desmond G.
dc.date.accessioned 2017-11-14T13:24:33Z
dc.date.available 2017-11-14T13:24:33Z
dc.date.issued 1997
dc.identifier.citation Thompson, J. D., Gibson, T. J., Plewniak, F., Jeanmougin, F. and Higgins, D. G. (1997) 'The CLUSTAL_X windows interface: flexible strategies for multiple sequence alignment aided by quality analysis tools', Nucleic Acids Research, 25(24), pp. 4876-4882. doi: 10.1093/nar/25.24.4876 en
dc.identifier.volume 25
dc.identifier.issued 24
dc.identifier.startpage 4876
dc.identifier.endpage 4882
dc.identifier.issn 0305-1048
dc.identifier.uri http://hdl.handle.net/10468/5038
dc.identifier.doi 10.1093/nar/25.24.4876
dc.description.abstract CLUSTAL X is a new windows interface for the widely-used progressive multiple sequence alignment program CLUSTAL W, The new system is easy to use, providing an integrated system for performing multiple sequence and profile alignments and analysing the results, CLUSTAL X displays the sequence alignment in a window on the screen, A versatile sequence colouring scheme allows the user to highlight conserved features in the alignment, Pull-down menus provide all the options required for traditional multiple sequence and profile alignment, New features include: the ability to cut-and-paste sequences to change the order of the alignment, selection of a subset of the sequences to be realigned, and selection of a sub-range of the alignment to be realigned and inserted back into the original alignment, Alignment quality analysis can be performed and low-scoring segments or exceptional residues can be highlighted, Quality analysis and realignment of selected residue ranges provide the user with a powerful tool to improve and refine difficult alignments and to trap errors in input sequences, CLUSTAL X has been compiled on SUN Solaris, IRIX5.3 on Silicon Graphics, Digital UNIX on DECstations, Microsoft Windows (32 bit) for PCs, Linux ELF for x86 PCs, and Macintosh PowerMac. en
dc.format.mimetype application/pdf en
dc.language.iso en en
dc.publisher Oxford University Press en
dc.relation.uri https://academic.oup.com/nar/article-lookup/doi/10.1093/nar/25.24.4876
dc.rights © 1997, Oxford University Press en
dc.subject Protein sequences en
dc.subject Secondary structure en
dc.subject Sensitivity en
dc.subject Weights en
dc.subject Profile en
dc.title The CLUSTAL_X windows interface: flexible strategies for multiple sequence alignment aided by quality analysis tools en
dc.type Article (peer-reviewed) en
dc.internal.authorcontactother Desmond G. Higgins, Biochemistry, University College Cork, Cork, Ireland. T: +353-21-490-3000 en
dc.internal.availability Full text available en
dc.description.version Published Version en
dc.contributor.funder Institut National de la Santé et de la Recherche Médicale
dc.contributor.funder Centre National de la Recherche Scientifique
dc.contributor.funder Ministère de l'Enseignement Supérieur, de la Recherche, de la Science et de la Technologie
dc.contributor.funder European Bioinformatics Institute
dc.description.status Peer reviewed en
dc.identifier.journaltitle Nucleic Acids Research en
dc.internal.IRISemailaddress jeanmougin@igbmc.u-strasbg.fr en


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