Gutsy moves: the amygdala as a critical node in microbiota to brain signaling

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dc.contributor.author Cowan, Caitlin S. M.
dc.contributor.author Hoban, Alan E.
dc.contributor.author Ventura-Silva, Ana Paula
dc.contributor.author Dinan, Timothy G.
dc.contributor.author Clarke, Gerard
dc.contributor.author Cryan, John F.
dc.date.accessioned 2017-12-04T16:26:08Z
dc.date.available 2017-12-04T16:26:08Z
dc.date.issued 2017-11-17
dc.identifier.citation Cowan, C. S. M., Hoban, A. E., Ventura-Silva, A. P., Dinan, T. G., Clarke, G. and Cryan, J. F. 'Gutsy Moves: The Amygdala as a Critical Node in Microbiota to Brain Signaling', BioEssays, 1700172 (12pp), In Press. doi:10.1002/bies.201700172 en
dc.identifier.startpage 1700172-1 en
dc.identifier.endpage 1700172-12 en
dc.identifier.issn 1521-1878
dc.identifier.uri http://hdl.handle.net/10468/5116
dc.identifier.doi 10.1002/bies.201700172
dc.description.abstract The amygdala is a key brain area regulating responses to stress and emotional stimuli, so improving our understanding of how it is regulated could offer novel strategies for treating disturbances in emotion regulation. As we review here, a growing body of evidence indicates that the gut microbiota may contribute to a range of amygdala-dependent brain functions from pain sensitivity to social behavior, emotion regulation, and therefore, psychiatric health. In addition, it appears that the microbiota is necessary for normal development of the amygdala at both the structural and functional levels. While further investigations are needed to elucidate the exact mechanisms of microbiota-to-amygdala communication, ultimately, this work raises the intriguing possibility that the gut microbiota may become a viable treatment target in disorders associated with amygdala dysregulation, including visceral pain, post-traumatic stress disorder, and beyond. en
dc.description.sponsorship Science Foundation Ireland (“HEALTHMARK”by Science Foundation Ireland (SFI), Ireland (16/ERA-HDHL/3362)) en
dc.format.mimetype application/pdf en
dc.language.iso en en
dc.publisher Wiley en
dc.rights © 2017 The Authors. BioEssays Published by WILEY Periodicals, Inc. This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited. en
dc.rights.uri https://creativecommons.org/licenses/by/4.0/ en
dc.subject Anxiety en
dc.subject Fear en
dc.subject Gut-brain axis en
dc.subject Limbic system en
dc.subject Pain en
dc.subject Social behavior en
dc.subject Stress en
dc.title Gutsy moves: the amygdala as a critical node in microbiota to brain signaling en
dc.type Article (peer-reviewed) en
dc.internal.authorcontactother John F Cryan, Department Of Anatomy & Neuroscience, University College Cork, Cork, Ireland. +353-21-490-3000 Email: j.cryan@ucc.ie en
dc.internal.availability Full text available en
dc.date.updated 2017-12-04T15:59:02Z
dc.description.version Published Version en
dc.internal.rssid 419813234
dc.contributor.funder Science Foundation Ireland en
dc.contributor.funder Horizon 2020 en
dc.contributor.funder European Commission en
dc.description.status Peer reviewed en
dc.identifier.journaltitle Bioessays en
dc.internal.copyrightchecked No !!CORA!! en
dc.internal.licenseacceptance Yes en
dc.internal.IRISemailaddress J.Cryan@ucc.ie en
dc.relation.project info:eu-repo/grantAgreement/SFI/SFI Research Centres/12/RC/2273/IE/Alimentary Pharmabiotic Centre (APC) - Interfacing Food & Medicine/ en
dc.relation.project info:eu-repo/grantAgreement/EC/H2020::CSA/696300/EU/The second coordination and support action for the JPI Healthy Diet for a Healthy Life/CSA JPI HDHL 2.0 en


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© 2017 The Authors. BioEssays Published by WILEY Periodicals, Inc. This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited. Except where otherwise noted, this item's license is described as © 2017 The Authors. BioEssays Published by WILEY Periodicals, Inc. This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
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