Is TB testing associated with increased blood interferon-gamma levels?

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dc.contributor.author Kennedy, Aideen E.
dc.contributor.author O'Mahony, Jim
dc.contributor.author Byrne, Noel
dc.contributor.author MacSharry, John
dc.contributor.author Sayers, Riona G.
dc.date.accessioned 2017-12-08T13:33:47Z
dc.date.available 2017-12-08T13:33:47Z
dc.date.issued 2017-10-23
dc.identifier.citation Kennedy, A. E., O’Mahony, J., Byrne, N., MacSharry, J. and Sayers, R. G. (2017) 'Is TB testing associated with increased blood interferon-gamma levels?', Frontiers in Veterinary Science, 4, 176 (9pp). doi: 10.3389/fvets.2017.00176 en
dc.identifier.volume 4
dc.identifier.startpage 1
dc.identifier.endpage 9
dc.identifier.issn 2297-1769
dc.identifier.uri http://hdl.handle.net/10468/5153
dc.identifier.doi 10.3389/fvets.2017.00176
dc.description.abstract The Republic of Ireland reports a relatively low prevalence of Johne’s disease (JD) compared to international counterparts. Postulated reasons for this include a lower average herd size and a grass-based production system. Ireland also engages in high levels of bovine tuberculosis (bTB) testing. As interferon-gamma (IFN-γ) is believed to play a key role in protecting against JD, it is our hypothesis that administration of purified protein derivative (PPD), as part of the bTB test, is associated with a systemic increase in IFN-γ production, which may potentially limit clinical progression of the disease. We studied 265 cows (202 Friesian and 63 “Non-Friesian,” e.g., JerseyX, Norwegian Red) to assess IFN-γ levels and Mycobacterium avium subspecies paratuberculosis (MAP) antibody response before and after the bTB test. As part of the compulsory annual bTB test, avian and bovine PPD were administered at two separate cervical sites. To assess IFN-γ production, blood samples were taken before and 72 h after PPD administration. MAP antibody response was assessed before and 10 days post-PPD administration. A significant increase in MAP antibody response was identified post-bTB compared to pre-bTB response (p < 0.001). Additionally, IFN-γ production significantly increased at the post-bTB time point (p < 0.001) compared to the pre-bTB test readings. This may indicate a beneficial effect of bTB testing in controlling JD. en
dc.format.mimetype application/pdf en
dc.language.iso en en
dc.publisher Frontiers Media en
dc.relation.uri https://www.frontiersin.org/articles/10.3389/fvets.2017.00176/full
dc.rights © 2017, Kennedy, O’Mahony, Byrne, MacSharry and Sayers. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. en
dc.rights.uri https://creativecommons.org/licenses/by/4.0/
dc.subject Johne’s disease en
dc.subject TB test en
dc.subject Interferon-gamma en
dc.subject Purified protein derivative en
dc.subject ELISA en
dc.title Is TB testing associated with increased blood interferon-gamma levels? en
dc.type Article (peer-reviewed) en
dc.internal.authorcontactother John MacSharry, Alimentary Pharmabiotic Centre, University College Cork, Cork, Ireland. +353-21-490-3000 Email: j.macsharry@ucc.ie en
dc.internal.availability Full text available en
dc.description.version Published Version en
dc.description.status Peer reviewed en
dc.identifier.journaltitle Frontiers in Veterinary Science en
dc.internal.IRISemailaddress j.macsharry@ucc.ie en
dc.identifier.articleid 176


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© 2017, Kennedy, O’Mahony, Byrne, MacSharry and Sayers. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. Except where otherwise noted, this item's license is described as © 2017, Kennedy, O’Mahony, Byrne, MacSharry and Sayers. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
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