Oxidative stress in pre-eclampsia; have we been looking in the wrong place?

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dc.contributor.author Williamson, Rachel D.
dc.contributor.author McCarthy, Cathal
dc.contributor.author McCarthy, Fergus P.
dc.contributor.author Kenny, Louise C.
dc.date.accessioned 2017-12-20T12:22:02Z
dc.date.available 2017-12-20T12:22:02Z
dc.date.issued 2017-01-18
dc.identifier.citation Williamson, R. D., McCarthy, C., McCarthy, F. P. and Kenny, L. C. (2017) ‘Oxidative stress in pre-eclampsia; have we been looking in the wrong place?’, Pregnancy Hypertension: An International Journal of Women's Cardiovascular Health, 8, pp. 1-5. doi:10.1016/j.preghy.2017.01.004 en
dc.identifier.volume 8 en
dc.identifier.startpage 1 en
dc.identifier.endpage 5 en
dc.identifier.issn 2210-7789
dc.identifier.uri http://hdl.handle.net/10468/5202
dc.identifier.doi 10.1016/j.preghy.2017.01.004
dc.description.abstract Pre-eclampsia is a disorder of late pregnancy. It is a major cause of maternal and perinatal morbidity and mortality, accounting for nearly 18% of all maternal deaths worldwide; an estimated 77,000 maternal deaths per year [1]. Poor placentation is considered to be an initial cause of the placental ischemia [2]. Placental ischemia in turn gives rise to oxidative stress in the placenta and leads to shedding of syncytiotrophoblast debris into the maternal circulation provoking a systemic maternal inflammatory response and release of sFLT and sENG causing maternal vascular endothelial dysfunction. The ubiquitous nature of the maternal vascular endothelium accounts for the diverse multi-system nature of pre-eclampsia. Currently there is no treatment for pre-eclampsia except delivery of the placenta and the baby, with the attendant risk of iatrogenic prematurity and significant neonatal morbidity and mortality. As a result, intensive research endeavours have focused on defining the molecular mechanisms of pre-eclampsia and the identification of new pre-symptomatic biomarkers of the condition. This review focuses on the role of elevated oxidative stress in the pathology of pre-eclampsia and potential therapeutic agents targeting oxidative stress that may prevent or ameliorate this disorder. en
dc.format.mimetype application/pdf en
dc.language.iso en en
dc.publisher Elsevier B.V. en
dc.rights © 2017, International Society for the Study of Hypertension in Pregnancy. Published by Elsevier B.V. All rights reserved. This manuscript version is made available under the CC-BY-NC-ND 4.0 license. en
dc.rights.uri http://creativecommons.org/licenses/by-nc-nd/4.0/ en
dc.subject Pre-eclampsia en
dc.subject Oxidative stress en
dc.title Oxidative stress in pre-eclampsia; have we been looking in the wrong place? en
dc.type Article (peer-reviewed) en
dc.internal.authorcontactother Louise Kenny, Obstetrics & Gynaecology, University College Cork, Cork, Ireland. +353-21-490-3000 Email: l.kenny@ucc.ie en
dc.internal.availability Full text available en
dc.check.info Access to this article is restricted until 12 months after publication by request of the publisher. en
dc.check.date 2018-01-18
dc.date.updated 2017-12-20T12:14:15Z
dc.description.version Accepted Version en
dc.internal.rssid 419970681
dc.description.status Peer reviewed en
dc.identifier.journaltitle Pregnancy Hypertension: An International Journal of Women's Cardiovascular Health en
dc.internal.copyrightchecked Yes en
dc.internal.licenseacceptance Yes en
dc.internal.IRISemailaddress L.Kenny@ucc.ie en
dc.internal.IRISemailaddress fergus.mccarthy@ucc.ie en


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© 2017, International Society for the Study of Hypertension in Pregnancy. Published by Elsevier B.V. All rights reserved. This manuscript version is made available under the CC-BY-NC-ND 4.0 license. Except where otherwise noted, this item's license is described as © 2017, International Society for the Study of Hypertension in Pregnancy. Published by Elsevier B.V. All rights reserved. This manuscript version is made available under the CC-BY-NC-ND 4.0 license.
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