The urgent need for a harmonized severity scoring system for acute allergic reactions

Show simple item record Muraro, Antonella Fernandez-Rivas, Montserrat Beyer, Kirsten Cardona, Victòria Clark, Andrew T. Eller, Esben Hourihane, Jonathan O'B. Jutel, Marek Sheikh, Aziz Agache, Ioana Allen, Katrina J. Angier, Liz Ballmer-Weber, Barbara Bilò, Maria Beatrice Bindslev-Jensen, Carsten Camargo, Carlos A. Cianferoni, Antonella Dunn Galvin, Audrey Eigenmann, Philippe A. Halken, Susanne Hoffmann-Sommergruber, Karin Lau, Susanne Nilsson, Caroline Poulsen, Lars K. Rueff, Franziska Spergel, Jonathan Sturm, Gunter Timmermans, Frans Torres, Maria J. Turner, Paul van Ree, Ronald Wickman, Magnus Worm, Margitta Clare Mills, E. N. Roberts, Graham 2018-01-18T16:58:02Z 2018-01-18T16:58:02Z 2018-01-13
dc.identifier.citation Muraro, A. et al. (2018) 'The urgent need for a harmonized severity scoring system for acute allergic reactions', Allergy, 73(9), pp. 1792-1800. doi:10.1111/all.13408 en
dc.identifier.volume 73
dc.identifier.issued 9
dc.identifier.startpage 1792
dc.identifier.startpage 1800
dc.identifier.issn 1398-9995
dc.identifier.doi 10.1111/all.13408
dc.description.abstract The accurate assessment and communication of the severity of acute allergic reactions is important to patients, clinicians, researchers, the food industry, public health and regulatory authorities. Severity has different meanings to different stakeholders with patients and clinicians rating the significance of particular symptoms very differently. Many severity scoring systems have been generated, most focusing on the severity of reactions following exposure to a limited group of allergens. They are heterogeneous in format, none has used an accepted developmental approach and none has been validated. Their wide range of outcome formats has led to difficulties with interpretation and application. Therefore there is a persisting need for an appropriately developed and validated severity scoring system for allergic reactions that works across the range of allergenic triggers and addresses the needs of different stakeholder groups. We propose a novel approach to develop and then validate a harmonized scoring system for acute allergic reactions, based on a data-driven method that is informed by clinical and patient experience and other stakeholders’ perspectives. We envisage two formats: (i) a numerical score giving a continuum from mild to severe reactions that is clinically meaningful and is useful for allergy healthcare professionals and researchers; and (ii) a three grade based ordinal format that is simple enough to be used and understood by other professionals and patients. Testing of reliability and validity of the new approach in a range of settings and populations will allow eventual implementation of a standardized scoring system in clinical studies and routine practice. en
dc.description.sponsorship European Academy of Allergy and Clinical Immunology (EAACI, as part of the Food Allergy and Anaphylaxis Guidelines Initiative) en
dc.format.mimetype application/pdf en
dc.language.iso en en
dc.publisher Wiley en
dc.rights © 2018, EAACI and John Wiley and Sons A/S. Published by John Wiley and Sons, Ltd. This is the peer reviewed version of the following article: Muraro, A. et al, ‘The urgent need for a harmonized severity scoring system for acute allergic reactions’, Allergy, 73(9), pp. 1792-1800, doi: 10.1111/all.13408, which has been published in final form at This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Self-Archiving. en
dc.subject Allergic reactions en
dc.subject Anaphylaxis en
dc.subject Angioedema en
dc.subject Asthma en
dc.subject Development en
dc.subject Drug allergy en
dc.subject Food allergy en
dc.subject Severity score en
dc.subject Urticarial en
dc.subject Validation en
dc.subject Venom allergy en
dc.title The urgent need for a harmonized severity scoring system for acute allergic reactions en
dc.type Article (peer-reviewed) en
dc.internal.authorcontactother Jonathan Hourihane, Paediatrics & Child Health, University College Cork, Cork, Ireland. +353-21-490-3000 Email: en
dc.internal.availability Full text available en Access to this article is restricted until 12 months after publication by request of the publisher. en 2019-01-13 2018-01-18T15:59:20Z
dc.description.version Accepted Version en
dc.internal.rssid 422302539
dc.contributor.funder Food Allergy Initiative en
dc.contributor.funder European Academy of Allergy and Clinical Immunology (EAACI) en
dc.description.status Peer reviewed en
dc.identifier.journaltitle Allergy en
dc.internal.copyrightchecked No !!CORA!! en
dc.internal.licenseacceptance Yes en
dc.internal.IRISemailaddress en

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