Exposure to hypertensive disorders of pregnancy increases the risk of autism spectrum disorder in affected offspring

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dc.contributor.author Curran, Eileen A.
dc.contributor.author O'Keeffe, Gerard W.
dc.contributor.author Looney, Ann Marie
dc.contributor.author Moloney, Gerard M.
dc.contributor.author Hegarty, Shane V.
dc.contributor.author Murray, Deirdre M.
dc.contributor.author Khashan, Ali S.
dc.contributor.author Kenny, Louise C.
dc.date.accessioned 2018-01-30T11:42:44Z
dc.date.available 2018-01-30T11:42:44Z
dc.date.issued 2017-10-03
dc.identifier.citation Curran, E. A., O’Keeffe, G. W., Looney, A. M., Moloney, G., Hegarty, S. V., Murray, D. M., Khashan, A. S. and Kenny, L. C. (2017) ‘Exposure to hypertensive disorders of pregnancy increases the risk of autism spectrum disorder in affected offspring’, Molecular Neurobiology, 55, pp. 5557–5564. doi:10.1007/s12035-017-0794-x en
dc.identifier.volume 55
dc.identifier.startpage 5557
dc.identifier.endpage 5564
dc.identifier.issn 1559-1182
dc.identifier.issn 0893-7648
dc.identifier.uri http://hdl.handle.net/10468/5344
dc.identifier.doi 10.1007/s12035-017-0794-x
dc.description.abstract There is growing awareness that prenatal adversity may increase the risk of autism spectrum disorder (ASD). Here, we examined the association between hypertensive disorders of pregnancy (HDP) and ASD risk at 7 years of age using the Millennium Cohort Study (MCS), a representative cohort of 13,192 children born in the UK from 2000 to 2001. We also sought to examine cytokine expression in the serum of women with pre-eclampsia, which is the most common HDP, and whether exposure of foetal neurons to this serum could change patterns of neuronal growth. HDP were reported by mothers 9 months post-delivery. ASD was parent reported at age seven, based on a doctor or health care professional’s diagnosis. Weighted logistic regression was used for data analysis, adjusting for several potential confounders including maternal alcohol consumption, education, depression, age, and poverty status. Sensitivity analyses were performed excluding pre-term births, small for gestational age (SGA), and pre-pregnancy hypertension and depression. There was a significant association between HDP and a twofold increased risk of ASD (AOR = 2.10 [95% CI 1.20–3.70]). Excluding preterm births, SGA births, and offspring of women who had pre-pregnancy hypertension or over the age of 40 did not change the results materially. At the cellular level, exposure of foetal cortical neurons to 3% serum isolated from women with an established HDP increased neuronal growth and branching in vitro. These findings indicate that HDP exposure may increase the risk of ASD in the offspring. en
dc.format.mimetype application/pdf en
dc.language.iso en en
dc.publisher Springer International Publishing AG en
dc.rights © 2017, Springer Science+Business Media, LLC. This is a post-peer-review, pre-copyedit version of an article published in Molecular Neurobiology. The final authenticated version is available online at: http://dx.doi.org/10.1007/s12035-017-0794-x en
dc.subject Autism spectrum disorder en
dc.subject ASD en
dc.subject Autism en
dc.subject Pre-eclampsia en
dc.subject Pregnancy en
dc.subject Hypertensive disorders en
dc.title Exposure to hypertensive disorders of pregnancy increases the risk of autism spectrum disorder in affected offspring en
dc.type Article (peer-reviewed) en
dc.internal.authorcontactother Louise Kenny, Obstetrics & Gynaecology, University College Cork, Cork, Ireland. +353-21-490-3000 Email: l.kenny@ucc.ie en
dc.internal.availability Full text available en
dc.check.info Access to this article is restricted until 12 months after publication by request of the publisher. en
dc.check.date 2018-10-03
dc.date.updated 2018-01-30T09:44:54Z
dc.description.version Accepted Version en
dc.internal.rssid 423828210
dc.contributor.funder Science Foundation Ireland en
dc.description.status Peer reviewed en
dc.identifier.journaltitle Molecular Neurobiology en
dc.internal.copyrightchecked Yes en
dc.internal.licenseacceptance Yes en
dc.internal.IRISemailaddress L.Kenny@ucc.ie en
dc.relation.project info:eu-repo/grantAgreement/SFI/SFI Research Centres/12/RC/2272/IE/Irish Centre for Fetal and Neonatal Translational Research (INFANT)/ en
dc.relation.project info:eu-repo/grantAgreement/SFI/SFI Career Development Award/15/CDA/3498/IE/Development of GDF5 neurotrophic factor therapy for Parkinson_s disease./ en

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