The impact of fatty acid desaturase genotype on fatty acid status and cardiovascular health in adults

Show simple item record O'Neill, Colette M. Minihane, Anne-Marie 2018-01-30T12:26:15Z 2018-01-30T12:26:15Z 2016-08-16
dc.identifier.citation O'Neill, C. M. and Minihane, A.-M. (2016) 'The impact of fatty acid desaturase genotype on fatty acid status and cardiovascular health in adults', Proceedings of the Nutrition Society, 76(1), pp. 64-75. doi: 10.1017/S0029665116000732 en
dc.identifier.volume 76 en
dc.identifier.issued 1 en
dc.identifier.startpage 64 en
dc.identifier.endpage 75 en
dc.identifier.issn 0029-6651
dc.identifier.doi 10.1017/S0029665116000732
dc.description.abstract The aim of this review was to determine the impact of the fatty acid desaturase (FADS) genotype on plasma and tissue concentrations of the long-chain (LC) n-3 PUFA, including EPA and DHA, which are associated with the risk of several diet-related chronic diseases, including CVD. In addition to dietary intakes, which are low for many individuals, tissue EPA and DHA are also influenced by the rate of bioconversion from α-linolenic acid (αLNA). Δ-5 and Δ-6 desaturase enzymes, encoded for by FADS1 and FADS2 genes, are key desaturation enzymes involved in the bioconversion of essential fatty acids (αLNA and linoleic acid (LA)) to longer chained PUFA. In general, carriers of FADS minor alleles tend to have higher habitual plasma and tissue levels of LA and αLNA, and lower levels of arachidonic acid, EPA and also to a lesser extent DHA. In conclusion, available research findings suggest that FADS minor alleles are also associated with reduced inflammation and CVD risk, and that dietary total fat and fatty acid intake have the potential to modify relationships between FADS gene variants and circulating fatty acid levels. However to date, neither the size-effects of FADS variants on fatty acid status, nor the functional SNP in FADS1 and 2 have been identified. Such information could contribute to the refinement and targeting of EPA and DHA recommendations, whereby additional LC n-3 PUFA intakes could be recommended for those carrying FADS minor alleles. en
dc.description.sponsorship Biotechnology and Biological Sciences Research Council (BBSRC Institute Strategic Programme grant (BB/J004545/1)) en
dc.format.mimetype application/pdf en
dc.language.iso en en
dc.publisher Cambridge University Press (CUP) en
dc.rights © The Authors 2016. en
dc.subject EPA en
dc.subject DHA en
dc.subject Arachidonic acid en
dc.subject Long-chain PUFA en
dc.subject Genotype en
dc.subject FADS en
dc.subject Cardiovascular en
dc.subject CVD en
dc.subject Fatty acid desaturase en
dc.subject Fatty acid en
dc.subject Cardiovascular health en
dc.subject α-linolenic acid en
dc.subject Linoleic acid en
dc.title The impact of fatty acid desaturase genotype on fatty acid status and cardiovascular health in adults en
dc.type Article (peer-reviewed) en
dc.internal.authorcontactother Colette M. O'Neill, Food & Nutritional Sciences, University College Cork, Cork, Ireland. +353-21-490-3000 en
dc.internal.availability Full text available en
dc.description.version Published Version en
dc.contributor.funder Seventh Framework Programme en
dc.contributor.funder Biotechnology and Biological Sciences Research Council en
dc.description.status Peer reviewed en
dc.identifier.journaltitle Proceedings of the Nutrition Society en
dc.internal.copyrightchecked !!CORA!! en
dc.relation.project info:eu-repo/grantAgreement/EC/FP7::SP1::KBBE/266486/EU/New dietary strategies addressing the specific needs of elderly population for an healthy ageing in Europe/NU-AGE en

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