Nisin in combination with cinnamaldehyde and EDTA to control growth of Escherichia coli strains of swine origin

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dc.contributor.author Field, Des
dc.contributor.author Baghou, Inès
dc.contributor.author Rea, Mary
dc.contributor.author Gardiner, Gillian E.
dc.contributor.author Ross, R. Paul
dc.contributor.author Hill, Colin
dc.date.accessioned 2018-02-06T13:36:29Z
dc.date.available 2018-02-06T13:36:29Z
dc.date.issued 2017
dc.identifier.citation Field, D., Baghou, I., Rea, M., Gardiner, G., Ross, R. and Hill, C. (2017) 'Nisin in combination with cinnamaldehyde and EDTA to control growth of Escherichia coli strains of swine origin', Antibiotics, 6(4), 35 (10pp). doi: 10.3390/antibiotics6040035 en
dc.identifier.volume 6
dc.identifier.issued 4
dc.identifier.startpage 1
dc.identifier.endpage 10
dc.identifier.uri http://hdl.handle.net/10468/5400
dc.identifier.doi 10.3390/antibiotics6040035
dc.description.abstract Post-weaning diarrhoea (PWD) due to enterotoxigenic Escherichia coli (ETEC) is an economically important disease in pig production worldwide. Although antibiotics have contributed significantly to mitigate the economic losses caused by PWD, there is major concern over the increased incidence of antimicrobial resistance among bacteria isolated from pigs. Consequently, suitable alternatives that are safe and effective are urgently required. Many naturally occurring compounds, including the antimicrobial peptide nisin and a number of plant essential oils, have been widely studied and are reported to be effective as antimicrobial agents against pathogenic microorganisms. Here, we evaluate the potential of nisin in combination with the essential oil cinnamaldehyde and ethylenediaminetetraacetic acid (EDTA) to control the growth of E. coli strains of swine origin including two characterized as ETEC. The results reveal that the use of nisin (10 μM) with low concentrations of trans-cinnamaldehyde (125 μg/mL) and EDTA (0.25–2%) resulted in extended lag phases of growth compared to when either antimicrobial is used alone. Further analysis through kill curves revealed that an approximate 1-log reduction in E. coli cell counts was observed against the majority of targets tested following 3 h incubation. These results highlight the potential benefits of combining the natural antimicrobial nisin with trans-cinnamaldehyde and EDTA as a new approach for the inhibition of E. coli strains of swine origin. en
dc.format.mimetype application/pdf en
dc.language.iso en en
dc.publisher MDPI AG en
dc.relation.uri http://www.mdpi.com/2079-6382/6/4/35
dc.rights © 2017, by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). en
dc.rights.uri http://creativecommons.org/licenses/by/4.0/
dc.subject Antimicrobial resistance en
dc.subject Antibiotics en
dc.subject Antimicrobial peptide en
dc.subject Enterotoxigenic E. coli en
dc.subject Nisin en
dc.subject Bacteriocin en
dc.subject Essential oil en
dc.subject Cinnamaldehyde en
dc.subject EDTA en
dc.title Nisin in combination with cinnamaldehyde and EDTA to control growth of Escherichia coli strains of swine origin en
dc.type Article (peer-reviewed) en
dc.internal.authorcontactother des.field@ucc.ie en
dc.internal.availability Full text available en
dc.description.version Published Version en
dc.contributor.funder Science Foundation Ireland
dc.description.status Peer reviewed en
dc.identifier.journaltitle Antibiotics en
dc.internal.IRISemailaddress Des Field, Microbiology, University College Cork, Cork, Ireland. +353-21-490-3000 E-mail: des.field@ucc.ie en
dc.identifier.articleid 35
dc.relation.project info:eu-repo/grantAgreement/SFI/SFI Research Centres/12/RC/2273/IE/Alimentary Pharmabiotic Centre (APC) - Interfacing Food & Medicine/
dc.relation.project info:eu-repo/grantAgreement/SFI/SFI Principal Investigator Programme (PI)/10/IN.1/B3027/IE/Lantibiotics: the next generation/


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© 2017, by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). Except where otherwise noted, this item's license is described as © 2017, by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
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