A comparative evaluation of surrogate measures of adiposity as indictors of cardiometabolic disease

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dc.contributor.advisor Phillips, Catherine en
dc.contributor.advisor Perry, Ivan J. en
dc.contributor.author Millar, Sean R.
dc.date.accessioned 2018-02-07T10:28:02Z
dc.date.issued 2016
dc.date.submitted 2016
dc.identifier.citation Millar, S. R. 2016. A comparative evaluation of surrogate measures of adiposity as indictors of cardiometabolic disease. PhD Thesis, University College Cork. en
dc.identifier.endpage 298 en
dc.identifier.uri http://hdl.handle.net/10468/5417
dc.description.abstract This thesis contributes to the current evidence base regarding methods to detect patients with type 2 diabetes, and those at increased obesity-related cardiometabolic risk. In particular, it aimed to determine how useful surrogate measures of adiposity might be to identify high-risk patients within a clinical setting. Using a cross-sectional sample of 2,047 middle-aged men and women, the main objectives were: (1) to examine the rationale for adiposity assessment within clinical practice, and whether methods used for disease classification and anthropometric measurement procedure are important for diagnosing cardiometabolic risk and type 2 diabetes; (2) to compare adiposity variable relationships with a range of cardiometabolic disease features, biomarkers of chronic low-grade inflammation and type 2 diabetes; (3) to explore whether central adiposity indices provide additional information regarding disease and risk status, compared to general adiposity characterised by body mass index (BMI); (4) to investigate the clinical utility of a composite index using both general and central adiposity measures. The results suggest that surrogate measures of central adiposity provide information regarding disease status and cardiometabolic risk, independent of that provided by BMI, and that a composite index using both BMI and central adiposity measures may help refine body fat classification. Earlier identification of patients at increased cardiometabolic risk, and those with type 2 diabetes, could allow earlier targeted interventions to be implemented, thus reducing the incidence of related complications, premature mortality and financial costs associated with the obesity epidemic. en
dc.description.sponsorship Health Research Board (HRC/2007/13) en
dc.format.mimetype application/pdf en
dc.language.iso en en
dc.publisher University College Cork en
dc.rights © 2016, Seán Russell Millar. en
dc.rights.uri http://creativecommons.org/licenses/by-nc-nd/3.0/ en
dc.subject Obesity measurement en
dc.subject Cardiometabolic risk en
dc.title A comparative evaluation of surrogate measures of adiposity as indictors of cardiometabolic disease en
dc.type Doctoral thesis en
dc.type.qualificationlevel Doctoral en
dc.type.qualificationname PhD (Medicine and Health) en
dc.internal.availability Full text not available en
dc.check.info Restricted to everyone for three years en
dc.check.date 2021-02-06T10:28:03Z
dc.description.version Accepted Version
dc.contributor.funder Health Research Board en
dc.description.status Not peer reviewed en
dc.internal.school Epidemiology and Public Health en
dc.check.reason This thesis is due for publication or the author is actively seeking to publish this material en
dc.check.opt-out Not applicable en
dc.thesis.opt-out false
dc.check.chapterOfThesis Chapter 5, pages 134-158
dc.check.embargoformat Both hard copy thesis and e-thesis en
ucc.workflow.supervisor i.perry@ucc.ie
dc.internal.conferring Summer 2017 en

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© 2016, Seán Russell Millar. Except where otherwise noted, this item's license is described as © 2016, Seán Russell Millar.
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