Predicted 10-year risk of cardiovascular mortality in the 40 to 69 year old general population without cardiovascular diseases in Germany

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dc.contributor.author Diederichs, Claudia
dc.contributor.author Neuhauser, Hannelore
dc.contributor.author Rücker, Viktoria
dc.contributor.author Busch, Markus A.
dc.contributor.author Keil, Ulrich
dc.contributor.author Fitzgerald, Anthony P.
dc.contributor.author Heuschmann, Peter U.
dc.date.accessioned 2018-02-20T12:45:13Z
dc.date.available 2018-02-20T12:45:13Z
dc.date.issued 2018-01-03
dc.identifier.citation Diederichs C, Neuhauser H, Rücker V, Busch MA, Keil U, Fitzgerald AP, et al. (2018) Predicted 10-year risk of cardiovascular mortality in the 40 to 69 year old general population without cardiovascular diseases in Germany. PLoS ONE 13(1): e0190441. https://doi.org/10.1371/journal.pone.0190441 en
dc.identifier.volume 13 en
dc.identifier.issued 1 en
dc.identifier.issn 1932-6203
dc.identifier.uri http://hdl.handle.net/10468/5488
dc.identifier.doi 10.1371/journal.pone.0190441
dc.description.abstract Aims To estimate the 10-year risk of fatal cardiovascular disease (CVD) in the 40 to 69 year old general population in Germany stratified by sex and to analyze differences between socio-economic status (SES), region and community size in individuals without CVD. The analysis is based on the newly recalibrated SCORE Deutschland risk charts and considered other comorbidities for the classification of the high CVD risk group according to the guidelines of the European Society of Cardiology. Methods and results In 3,498 participants (40–69 years) from the German Health Examination Survey for Adults 2008–2011 (DEGS1) without a history of CVD (myocardial infarction, coronary heart disease, heart failure, stroke) we estimated the proportion with a low (SCORE <1%), moderate (SCORE 1-<5%) and high 10-year CVD mortality risk (SCORE ≥5% or diabetes, renal insufficiency, SBP/DPB ≥180/110 mmHg or cholesterol >8 mmol/l). The prevalence of low, moderate and high risk was 42.8%, 38.5% and 18.8% in men and 73.7%, 18.1% and 8.2% in women. The prevalence of high risk was significantly lower in women with a high compared to a low SES (3.3% vs. 11.2%) and in communities with ≥100.000 inhabitants compared to <20.000 inhabitants (5.4% vs.10.9%). There were no significant associations between predicted CVD mortality risk and SES or community size in men and regions in men and women. Among the high risk group, 58.2% of men and 9.8% of women had SCORE ≥5%, leaving the majority of women (60.1%) classified as high risks due to diabetes and SCORE <5%. Conclusion Our results suggest the persistence of socioeconomic disparities in predicted cardiovascular mortality in women and support the need of large-scale prevention efforts beyond individual lifestyle modification or treatment. Furthermore, the importance of additional comorbidities for the high risk group classification is highlighted. en
dc.description.sponsorship DZHK (German Centre for Cardiovascular Research) grant number MDC2012Z1 en
dc.format.mimetype application/pdf en
dc.language.iso en en
dc.publisher Public Library of Science en
dc.rights © 2018 Diederichs et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. en
dc.rights.uri https://creativecommons.org/licenses/by/4.0/ en
dc.subject Cardiovascular mortality en
dc.subject Cardiovascular diseases en
dc.subject Germany en
dc.subject 40 to 69 years en
dc.title Predicted 10-year risk of cardiovascular mortality in the 40 to 69 year old general population without cardiovascular diseases in Germany en
dc.type Article (peer-reviewed) en
dc.internal.authorurl Tony Fitzgerald, Epidemiology & Public Health, University College Cork, Cork, Ireland. +353-21-490-3000 Email: t.fitzgerald@ucc.ie en
dc.internal.availability Full text available en
dc.description.version Published Version en
dc.contributor.funder Deutsches Zentrum für Herz-Kreislaufforschung en
dc.contributor.funder Bundesministerium für Bildung und Forschung en
dc.contributor.funder Bundesministerium für Gesundheit en
dc.description.status Peer reviewed en
dc.identifier.journaltitle PLoS ONE en
dc.identifier.articleid e0190441


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© 2018 Diederichs et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Except where otherwise noted, this item's license is described as © 2018 Diederichs et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
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