The effect of berry-based food interventions on markers of cardiovascular and metabolic health: A systematic review of randomized controlled trials
Heneghan, Clara; Kiely, Mairead E.; Lyons, Jacqueline; Lucey, Alice J.
Date:
2018-01-10
Copyright:
© 2017 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim. This is the peer reviewed version of the following article: C. Heneghan, M. Kiely, J. Lyons, A. Lucey, ‘The Effect of Berry-Based Food Interventions on Markers of Cardiovascular and Metabolic Health: A Systematic Review of Randomized Controlled Trials,’ Mol. Nutr. Food Res. 2018, 62, 1700645, which has been published in final form at http://dx.doi.org/10.1002/mnfr.201700645. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Self-Archiving.
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Access to this article is restricted until 12 months after publication by request of the publisher.
Restriction lift date:
2019-01-10
Citation:
Heneghan, C., Kiely, M., Lyons, J. and Lucey, A. (2018) 'The Effect of Berry-Based Food Interventions on Markers of Cardiovascular and Metabolic Health: A Systematic Review of Randomized Controlled Trials', Molecular Nutrition & Food Research, 62(1), 1700645 (12pp). doi: 10.1002/mnfr.201700645
Abstract:
Scope: Epidemiological evidence, animal, and in vitro studies suggest that berry consumption may ameliorate markers of cardiovascular disease (CVD). The aim of this systematic review is to evaluate findings from berry-based randomized controlled trials (RCTs) to establish the effects of berry consumption on markers of cardiovascular and metabolic health. Methods and results: PubMed and Web of Science are searched for RCTs investigating berry consumption on CVD risk outcomes in adults. A total of 23 studies (which includes 1168 participants) out of 1384 records meet the inclusion criteria. Of these 23 studies, 17 RCTs are of high quality, where 12 RCTs (71%) report beneficial effects of berry consumption on CVD risk markers. Overall, 4/11 RCTs that observe a reduction in systolic and/or diastolic blood pressure (BP); 3/7 RCTs report favorable effects on endothelial function, 2/3 RCTs report improvements in arterial stiffness, 7/17 studies observe benefits in blood lipids, and 3/6 studies report improvements in glycemic profile. Conclusion: Our evaluation of the literature indicates that more than two-thirds of high-quality trials have reported beneficial effects of berry consumption on markers of CVD risk. This systematic review contributes moderate to strong evidence for the inclusion of berries as part of a cardioprotective diet.
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