Standardized parenteral nutrition for the transition phase in preterm infants: a bag that fits

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dc.contributor.author Brennan, Ann-Marie
dc.contributor.author Kiely, Mairead E.
dc.contributor.author Fenton, Sarah
dc.contributor.author Murphy, Brendan
dc.date.accessioned 2018-03-09T12:55:07Z
dc.date.available 2018-03-09T12:55:07Z
dc.date.issued 2018
dc.identifier.citation Brennan, A.-M., Kiely, M., Fenton, S. and Murphy, B. (2018) 'Standardized parenteral nutrition for the transition phase in preterm infants: a bag that fits', Nutrients, 10(2), 170 (11pp). doi: 10.3390/nu10020170 en
dc.identifier.volume 10
dc.identifier.issued 1
dc.identifier.startpage 1
dc.identifier.endpage 11
dc.identifier.issn 2072-6643
dc.identifier.uri http://hdl.handle.net/10468/5611
dc.identifier.doi 10.3390/nu10020170
dc.description.abstract The optimal composition of standardized parenteral nutrition (SPN) is not yet known, contributing to nutrient deficit accrual and growth failure, with the period of parenteral nutrition weaning, i.e., transition (TN) phase, being identified as particularly vulnerable. We created a comprehensive nutrition database, representative of the nutritional course of a diverse range of preterm infants (n = 59, birth weight ≤ 1500 g, gestation < 34 weeks) by collecting hourly macronutrient intake data as part of a prospective, observational study over 19 months. Using a nutrient modeling technique for the TN phase, various amino acid (AA) concentrations of SPN were tested within the database, whilst acknowledging the nutritional contribution from enteral feeds until target AA intakes were consistently achieved. From the modeling, the AA composition of SPN was determined at 3.5 g/100 mL, which was the maximum to avoid exceeding target intakes at any point in the TN phase. However, in order to consistently achieve target AA intakes, additional nutritional strategies were required, which included increasing the exclusion of enteral feeds in fluid and nutrient calculations from <20 mL/kg/day to <40 mL/kg/day, and earlier fortification of breastmilk at 80 mL/kg/day. This data-driven nutrient modeling process supported the development of an improved SPN regimen for our preterm population in the TN phase. en
dc.description.sponsorship Science Foundation Ireland (PINPOINT project (Personalised nutrition for the preterm infant; 13SP INFANT B2888) en
dc.format.mimetype application/pdf en
dc.language.iso en en
dc.publisher MDPI AG en
dc.relation.uri http://www.mdpi.com/2072-6643/10/2/170
dc.rights © 2018, the Authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/) en
dc.rights.uri http://creativecommons.org/licenses/by/4.0/
dc.subject Standardized parenteral nutrition en
dc.subject Transition phase en
dc.subject Nutrient modeling en
dc.subject Amino acids en
dc.subject Enteral nutrition en
dc.subject Preterm infants en
dc.title Standardized parenteral nutrition for the transition phase in preterm infants: a bag that fits en
dc.type Article (peer-reviewed) en
dc.internal.authorcontactother Mairead Kiely, Food & Nutritional Sciences, University College Cork, Cork, Ireland. +353-21-490-3000 Email: m.kiely@ucc.ie en
dc.internal.availability Full text available en
dc.description.version Published Version en
dc.contributor.funder Science Foundation Ireland
dc.description.status Peer reviewed en
dc.identifier.journaltitle Nutrients en
dc.identifier.articleid 170
dc.relation.project info:eu-repo/grantAgreement/SFI/SFI Spokes Programme/13/SP INFANT/B2888/IE/Personalise Nutrition for the Preterm Infant (PiNPoiNT)/


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© 2018, the Authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/) Except where otherwise noted, this item's license is described as © 2018, the Authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/)
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