Placental Growth Factor: A review of literature and future applications

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Placental Growth Factor: A review of literature and future applications

Hayes Ryan, Deirdre; McCarthy, Fergus P.; O'Donoghue, Keelin; Kenny, Louise C.
Date: 2018-03-10
Copyright: © 2018 International Society for the Study of Hypertension in Pregnancy. Published by Elsevier B.V. All rights reserved. This manuscript version is made available under the CC-BY-NC-ND 4.0 license.
Copyright information: http://creativecommons.org/licenses/by-nc-nd/4.0/
Related: https://www.sciencedirect.com/science/article/pii/S2210778917304762
Full text restriction information: Access to this article is restricted until 12 months after publication by request of the publisher.
Restriction lift date: 2019-03-10
Citation: Hayes Ryan, D., McCarthy, F. P., O'Donoghue, K. and Kenny, L. C. 'Placental Growth Factor: A review of literature and future applications', Pregnancy Hypertension, In Press. doi: 10.1016/j.preghy.2018.03.003
Published Version: 10.1016/j.preghy.2018.03.003

Abstract:

Placental growth factor is an angiogenic protein, highly expressed during pregnancy, which correlates well with placental function. In this review, we highlight the origin, structure and function of Placental Growth Factor and its receptors. We discuss how their pro-angiogenic/anti-angiogenic synergism is critical for successful placentation and how their imbalance may be utilised as a diagnostic marker of disease or a potential therapeutic target for adverse pregnancy outcomes.

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© 2018 International Society for the Study of Hypertension in Pregnancy. Published by Elsevier B.V. All rights reserved. This manuscript version is made available under the CC-BY-NC-ND 4.0 license. Except where otherwise noted, this item's license is described as © 2018 International Society for the Study of Hypertension in Pregnancy. Published by Elsevier B.V. All rights reserved. This manuscript version is made available under the CC-BY-NC-ND 4.0 license.
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