Benzodiazepine and Z-drug prescribing in Ireland: analysis of national prescribing trends from 2005-2015

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dc.contributor.author Cadogan, Cathal A.
dc.contributor.author Ryan, Cristí­n
dc.contributor.author Cahir, Caitriona
dc.contributor.author Bradley, Colin P.
dc.contributor.author Bennett, Kathleen
dc.date.accessioned 2018-03-22T09:56:30Z
dc.date.available 2018-03-22T09:56:30Z
dc.date.issued 2018-02-28
dc.identifier.citation Cadogan, C. A., Ryan, C., Cahir, C., Bradley, C. P. and Bennett, K. (2018) 'Benzodiazepine and Z-drug prescribing in Ireland: analysis of national prescribing trends from 2005-2015', British Journal of Clinical Pharmacology, 84(6), pp. 1354-1363. doi:10.1111/bcp.13570 en
dc.identifier.volume 84
dc.identifier.issued 6
dc.identifier.startpage 1354
dc.identifier.endpage 1363
dc.identifier.issn 1365-2125
dc.identifier.issn 1365-2125
dc.identifier.uri http://hdl.handle.net/10468/5674
dc.identifier.doi 10.1111/bcp.13570
dc.description.abstract Aims: To examine prescribing trends for benzodiazepines and Z-drugs to General Medical Services (GMS) patients in Ireland. Methods: A repeated cross-sectional analysis of the national pharmacy claims database was conducted for GMS patients aged =16 years from 2005-2015. Prescribing rates per 1000 eligible GMS population were calculated with 95% confidence intervals (CIs). Negative binomial regression was used to determine longitudinal trends and compare prescribing rates across years, gender and age groups. Duration of supply and rates of concomitant benzodiazepine and Z-drug prescribing were determined. Age (16-44, 45-64, =65 years) and gender trends were investigated. Results: Benzodiazepine prescribing rates significantly decreased from 225.92/1000 population (95% CI 224.94-226.89) in 2005 to 166.07/1000 population (95% CI 165.38-166.75) in 2015 (p90 days) for either benzodiazepines or Z-drugs. The proportion of those receiving >1 benzodiazepine and/or Z-drug concomitantly increased from 11.9% in 2005 to 15.3% in 2015. Benzodiazepine and Z-drug prescribing rates were highest for older women (=65 years) throughout the study period. Conclusions: Benzodiazepine prescribing to the GMS population in Ireland significantly decreased from 2005 to 2015, and was coupled with significant increases in Z-drug prescribing. The study shows that benzodiazepine and Z-drug prescribing is common in this population, with a third receiving long-term prescriptions. Targeted interventions are needed to reduce potentially inappropriate long-term prescribing and use of these medications in Ireland. en
dc.format.mimetype application/pdf en
dc.language.iso en en
dc.publisher John Wiley & Sons, Inc. on behalf of the British Pharmacological Society en
dc.rights © 2018, John Wiley & Sons Inc. This is the peer reviewed version of the following article: Cadogan, C. A., Ryan, C., Cahir, C., Bradley, C. P. and Bennett, K. (2018) 'Benzodiazepine and Z-drug prescribing in Ireland: analysis of national prescribing trends from 2005-2015', British Journal of Clinical Pharmacology, 84(6), pp. 1354-1363, doi:10.1111/bcp.13570. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Self-Archiving. en
dc.subject Benzodiazepines en
dc.subject Z-drugs en
dc.subject Potentially inappropriate prescribing en
dc.subject Primary care en
dc.title Benzodiazepine and Z-drug prescribing in Ireland: analysis of national prescribing trends from 2005-2015 en
dc.type Article (peer-reviewed) en
dc.internal.authorcontactother Colin Bradley, General Practice, University College Cork, Cork, Ireland. +353-21-490-3000 Email: c.bradley@ucc.ie en
dc.internal.availability Full text available en
dc.check.info Access to this article is restricted until 12 months after publication by request of the publisher. en
dc.check.date 2019-02-28
dc.date.updated 2018-03-12T10:17:31Z
dc.description.version Accepted Version en
dc.internal.rssid 429271307
dc.description.status Peer reviewed en
dc.identifier.journaltitle British Journal of Clinical Pharmacology en
dc.internal.copyrightchecked Yes en
dc.internal.licenseacceptance Yes en
dc.internal.IRISemailaddress C.Bradley@ucc.ie en


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