Expressional changes in stemness markers post electrochemotherapy in pancreatic cancer cells

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dc.contributor.author Ali, Shahzad
dc.contributor.author Gill, Kheshwant S.
dc.contributor.author Saglio, Giuseppe
dc.contributor.author Cilloni, Daniela
dc.contributor.author Soden, Declan M.
dc.contributor.author Forde, Patrick F.
dc.date.accessioned 2018-03-26T11:47:14Z
dc.date.available 2018-03-26T11:47:14Z
dc.date.issued 2018-03-15
dc.identifier.citation Ali, S., Gill, K. S., Saglio. G., Cilloni, D., Soden, D. M. and Forde, P. F. (2018) 'Expressional changes in stemness markers post electrochemotherapy in pancreatic cancer cells', Bioelectrochemistry. doi:10.1016/j.bioelechem.2018.03.009 en
dc.identifier.issn 1567-5394
dc.identifier.issn 1878-562X
dc.identifier.uri http://hdl.handle.net/10468/5693
dc.identifier.doi 10.1016/j.bioelechem.2018.03.009
dc.description.abstract Pancreatic cancer is one of the most lethal cancers with high metastatic potential and strong chemoresistance. The capability of a tumor to grow and propagate is dependent on a small subset of cells within a tumor, termed cancer stem cells. Cancer stem cells exhibit great tumorigenicity and are closely correlated with drug resistance and tumor recurrence. The aim of our study was to illustrate electrochemotherapy as an effective treatment for pancreatic cancer along with the expression change in stemness genes (Nanog, Sox2 and Oct3/4) in pancreatic cancer cells post electrochemotherapy with bleomycin, cisplatin and oxaliplatin. Our results showed the enhanced expression of Nanog and decreased expression level of Oct3/4 after electrochemotherpy. We thus propose that these stemness markerS may have important roles in the initiation and/or recurrence of pancreatic cancer, and consequently may serve as important molecular diagnostics and/or therapeutic targets for the development of novel treatment strategies in pancreatic cancer patients. In conclusion, targeting these stemness factors could potentially improve electrochemotherapy as a treatment and preventing recurrence. en
dc.format.mimetype application/pdf en
dc.language.iso en en
dc.publisher Elsevier B.V. en
dc.rights © 2018, Elsevier B.V. All rights reserved. This manuscript version is made available under the CC-BY-NC-ND 4.0 license. en
dc.rights.uri https://creativecommons.org/licenses/by-nc-nd/4.0/ en
dc.subject Pancreatic en
dc.subject Stemness en
dc.subject Recurrence en
dc.subject Electrochemotherapy en
dc.title Expressional changes in stemness markers post electrochemotherapy in pancreatic cancer cells en
dc.type Article (peer-reviewed) en
dc.internal.authorcontactother Patrick Forde, Surgery, University College Cork, Cork, Ireland. +353-21-490-3000 Email: p.forde@ucc.ie en
dc.internal.availability Full text available en
dc.check.info Access to this article is restricted until 24 months after publication by request of the publisher. en
dc.check.date 2020-03-15
dc.date.updated 2018-03-21T11:43:34Z
dc.description.version Accepted Version en
dc.internal.rssid 430661888
dc.contributor.funder Breakthrough Cancer Research, Ireland
dc.contributor.funder Cork Cancer Research Centre, College of Medicine and Health, University College Cork
dc.contributor.funder Teddy Daly Memorial Fund, Ireland
dc.description.status Peer reviewed en
dc.identifier.journaltitle Bioelectrochemistry en
dc.internal.copyrightchecked Yes en
dc.internal.licenseacceptance Yes en
dc.internal.IRISemailaddress p.forde@ucc.ie en
dc.internal.bibliocheck In Press. Check for vol. / issue / page numbers. Amend citation as necessary.


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© 2018, Elsevier B.V. All rights reserved.  This manuscript version is made available under the CC-BY-NC-ND 4.0 license. Except where otherwise noted, this item's license is described as © 2018, Elsevier B.V. All rights reserved. This manuscript version is made available under the CC-BY-NC-ND 4.0 license.
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