Exploring gastric emptying rate in mini-pigs: Effect of food type and pre-dosing of metoclopramide

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dc.contributor.author Henze, Laura J.
dc.contributor.author Griffin, Brendan T.
dc.contributor.author Christiansen, Martin
dc.contributor.author Bundgaard, Christoffer
dc.contributor.author Langguth, Peter
dc.contributor.author Holm, René
dc.date.accessioned 2018-03-27T11:17:39Z
dc.date.available 2018-03-27T11:17:39Z
dc.date.issued 2018-03-17
dc.identifier.citation Henze, L. J., Griffin, B. T., Christiansen, M., Bundgaard, C., Langguth, P. and Holm, R. (2018) 'Exploring gastric emptying rate in mini-pigs: Effect of food type and pre-dosing of metoclopramide', European Journal of Pharmaceutical Sciences, In Press. doi: 10.1016/j.ejps.2018.03.017 en
dc.identifier.startpage 1 en
dc.identifier.endpage 32 en
dc.identifier.issn 0928-0987
dc.identifier.uri http://hdl.handle.net/10468/5697
dc.identifier.doi 10.1016/j.ejps.2018.03.017
dc.description.abstract The present study investigated the gastric emptying rate in Göttingen minipigs pre- and post-prandial and evaluated the effect of metoclopramide on the same parameter, using paracetamol as an absorption marker. The pharmacokinetic evaluation of the obtained plasma concentration data for paracetamol demonstrated that the fastest gastric emptying rate was observed in the animals that were allowed access to normal pig food. There was no significant difference in the stomach emptying rate observed between fasted and fed minipigs, when fed either with a FDA standard breakfast or a nutritional energy drink. Pre-dosing minipigs with metoclopramide (0.2 or 0.4 mg/kg) did not demonstrate any effect on gastric emptying in either the fasted or fed state. The data in the present study demonstrated a relatively prolonged gastric emptying rate in mini-pigs both in the fasted and fed state, hence when conducting pharmacokinetic studies using mini-pigs, this should be taken into account in planning the plasma sampling time points. Further, as no difference could be observe in gastric emptying rate as a function of food the data also suggest that the Göttingen minipigs seems less suited to predict for food effect studies than other species. en
dc.format.mimetype application/pdf en
dc.language.iso en en
dc.publisher Elsevier en
dc.relation.uri http://www.sciencedirect.com/science/article/pii/S0928098718301325
dc.rights © 2018 Elsevier B.V. All rights reserved. This manuscript version is made available under the CC-BY-NC-ND 4.0 license. en
dc.rights.uri https://creativecommons.org/licenses/by-nc-nd/4.0/ en
dc.subject Gastric emptying en
dc.subject Mini-pigs en
dc.subject Metoclopramide en
dc.subject Fasted state en
dc.subject Fed state en
dc.title Exploring gastric emptying rate in mini-pigs: Effect of food type and pre-dosing of metoclopramide en
dc.type Article (peer-reviewed) en
dc.internal.authorcontactother Laura J. Henze, School Of Pharmacy, University College Cork, Cork, Ireland. +353-21-490-3000 Email: laura.henze@ucc.ie en
dc.internal.availability Full text available en
dc.check.info Access to this article is restricted until 12 months after publication by request of the publisher. en
dc.check.date 2019-03-17
dc.date.updated 2018-03-27T11:10:52Z
dc.description.version Accepted Version en
dc.internal.rssid 431546832
dc.contributor.funder Horizon 2020 en
dc.description.status Peer reviewed en
dc.identifier.journaltitle European Journal of Pharmaceutical Sciences en
dc.internal.copyrightchecked No !!CORA!! en
dc.internal.licenseacceptance Yes en
dc.internal.IRISemailaddress laura.henze@ucc.ie en
dc.internal.bibliocheck In Press March 2018. Update citation details, page numbers, add volume, issue etc en
dc.relation.project info:eu-repo/grantAgreement/EC/H2020::MSCA-ITN-ETN/674909/EU/Pharmaceutical Education And Research with Regulatory Links: Innovative drug development strategies and regulatory tools tailored to facilitate earlier access to medicines/PEARRL en


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© 2018 Elsevier B.V. All rights reserved. This manuscript version is made available under the CC-BY-NC-ND 4.0 license. Except where otherwise noted, this item's license is described as © 2018 Elsevier B.V. All rights reserved. This manuscript version is made available under the CC-BY-NC-ND 4.0 license.
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