The expanding horizon of alkyl quinolone signalling and communication in polycellular interactomes

Show simple item record

dc.contributor.author Reen, F. Jerry
dc.contributor.author McGlacken, Gerard P.
dc.contributor.author O'Gara, Fergal
dc.date.accessioned 2018-04-05T08:48:36Z
dc.date.available 2018-04-05T08:48:36Z
dc.date.issued 2018-03-26
dc.identifier.citation Reen, F. J., McGlacken, G. P. and O'Gara, F. (2018) 'The expanding horizon of alkyl quinolone signalling and communication in polycellular interactomes', FEMS Microbiology Letters. doi:10.1093/femsle/fny076 en
dc.identifier.issn 0378-1097
dc.identifier.issn 1574-6968
dc.identifier.uri http://hdl.handle.net/10468/5735
dc.identifier.doi 10.1093/femsle/fny076
dc.description.abstract Population dynamics within natural ecosystems is underpinned by microbial diversity and the heterogeneity of host-microbe and microbe-microbe interactions. Small molecule signals that intersperse between species have been shown to govern many virulence-related processes in established and emerging pathogens. Understanding the capacity of microbes to decode diverse languages and adapt to the presence of ‘non-self’ cells, will provide an important new direction to the understanding of the ‘polycellular’ interactome. Alkyl Quinolones (AQs) have been described in the ESKAPE pathogen Pseudomonas aeruginosa, the primary agent associated with mortality in patients with Cystic Fibrosis and the third most prevalent nosocomial pathogen worldwide. The role of these molecules in governing the physiology and virulence of P. aeruginosa and other pathogens has received considerable attention, while a role in interspecies and interkingdom communication has recently emerged. Herein we discuss recent advances in our understanding of AQ signalling and communication in the context of microbe-microbe and microbe-host interactions. The integrated knowledge from these systems-based investigations will facilitate the development of new therapeutics based on the AQ framework that serve to disarm the pathogenesis of P. aeruginosa and competing pathogens. en
dc.description.sponsorship Enterprise Ireland (CF-2017-0757-P); Department of Agriculture, Food and the Marine (FIRM 1/F009/MabS; FIRM13/F/516); Irish Research Council for Science, Engineering and Technology (GOIPG/2014/647); Health Research Board/Irish Thoracic Society (MRCG-2014-6) en
dc.format.mimetype application/pdf en
dc.language.iso en en
dc.publisher Oxford University Press on behalf of Federation of European Microbiological Societies en
dc.rights © 2018, Federation of European Microbiological Societies. Published by Oxford University Press. All rights reserved. This is a pre-copyedited, author-produced PDF of an article accepted for publication in FEMS Microbiology Letters following peer review. The version of record, Reen, F. J., McGlacken, G. P. and O'Gara, F. (2018) 'The expanding horizon of alkyl quinolone signalling and communication in polycellular interactomes', is available online at: https://doi.org/10.1093/femsle/fny076 en
dc.subject Pseudomonas aeruginosa en
dc.subject Pseudomonas Quinolone Signal en
dc.subject PQS en
dc.subject Alkylquinolones en
dc.subject Anti-infectives en
dc.subject Interspecies signalling en
dc.subject Quorum sensing en
dc.title The expanding horizon of alkyl quinolone signalling and communication in polycellular interactomes en
dc.type Review en
dc.internal.authorcontactother F.Jerry Reen, Microbiology, University College Cork, Cork, Ireland. +353-21-490-3000 Email: j.reen@ucc.ie en
dc.internal.availability Full text available en
dc.check.info Access to this article is restricted until 12 months after publication by request of the publisher. en
dc.check.date 2019-03-26
dc.date.updated 2018-04-03T09:19:50Z
dc.description.version Accepted Version en
dc.internal.rssid 432431877
dc.contributor.funder Enterprise Ireland en
dc.contributor.funder Seventh Framework Programme en
dc.contributor.funder Horizon 2020 en
dc.contributor.funder Science Foundation Ireland en
dc.contributor.funder Department of Agriculture, Food and the Marine en
dc.contributor.funder Irish Research Council for Science, Engineering and Technology en
dc.contributor.funder Health Research Board en
dc.contributor.funder Irish Thoracic Society
dc.description.status Peer reviewed en
dc.identifier.journaltitle FEMS Microbiology Letters en
dc.internal.copyrightchecked Yes en
dc.internal.licenseacceptance Yes en
dc.internal.IRISemailaddress J.Reen@ucc.ie en
dc.internal.bibliocheck In Press. Check for vol. / issue / page numbers / supplementary files. Amend citation as necessary.
dc.relation.project info:eu-repo/grantAgreement/EC/FP7::SP3::PEOPLE/607786/EU/BluePharmTrain/BLUEPHARMTRAIN en
dc.relation.project info:eu-repo/grantAgreement/EC/FP7::SP1::KBBE/312184/EU/Increasing Value and Flow in the Marine Biodiscovery Pipeline/PHARMASEA en
dc.relation.project info:eu-repo/grantAgreement/EC/FP7::SP1::KBBE/311975/EU/Marine Microorganisms: Cultivation Methods for Improving their Biotechnological Applications/MACUMBA en
dc.relation.project info:eu-repo/grantAgreement/EC/FP7::SP1::KBBE/287589/EU/Marine Microbial Biodiversity, Bioinformatics and Biotechnology/MICRO B3 en
dc.relation.project info:eu-repo/grantAgreement/EC/H2020::IA/634486/EU/Industrial Applications of Marine Enzymes: Innovative screening and expression platforms to discover and use the functional protein diversity from the sea/INMARE en
dc.relation.project info:eu-repo/grantAgreement/SFI/SFI Research Centres/12/RC/2275/IE/Synthesis and Solid State Pharmaceutical Centre (SSPC)/ en
dc.relation.project info:eu-repo/grantAgreement/SFI/SFI Technology and Innovation Development Award (TIDA)/13/TIDA/B2625/IE/Small molecule inhibitors of HIF-1: a new class of anti-cancer therapeutics./ en
dc.relation.project info:eu-repo/grantAgreement/SFI/SFI Technology and Innovation Development Award (TIDA)/12/TIDA/B2411/IE/Development of small molecule therapeutics for medical intervention: anti-biofilm inhibitors for the medical device sector./ en
dc.relation.project info:eu-repo/grantAgreement/SFI/SFI Technology and Innovation Development Award (TIDA)/12/TIDA/B2405/IE/Optimised detection of key biomarkers of Pseudomonas aeruginosa towards a clinical application/ en
dc.relation.project info:eu-repo/grantAgreement/SFI/SFI Technology and Innovation Development Award (TIDA)/14/TIDA/2438/IE/Next Generation Antibiotics: anti-biofilm, anti-pathogenic natural bioactives from marine microorganisms./ en
dc.relation.project info:eu-repo/grantAgreement/SFI/SFI Technology and Innovation Development Award (TIDA)/15/TIDA/2977/IE/Pre-clinical testing of novel fungal biofilm blockers for the medical device sector./ en
dc.relation.project info:eu-repo/grantAgreement/SFI/SFI Investigator Programme/12/IP/1315/IE/The Direct Arylation of Pyrones, Coumarins, Pyridones and Quinolones/ en


Files in this item

This item appears in the following Collection(s)

Show simple item record

This website uses cookies. By using this website, you consent to the use of cookies in accordance with the UCC Privacy and Cookies Statement. For more information about cookies and how you can disable them, visit our Privacy and Cookies statement