Lipase catalysed kinetic resolutions of 3-aryl alkanoic acids

Show simple item record Deasy, Rebecca E. Brossat, Maude Moody, Thomas S. Maguire, Anita R. 2012-05-02T15:33:23Z 2012-05-02T15:33:23Z 2011 2011-02-02
dc.identifier.citation DEASY, R. E., BROSSAT, M., MOODY, T. S. & MAGUIRE, A. R. 2011. Lipase catalysed kinetic resolutions of 3-aryl alkanoic acids. Tetrahedron: Asymmetry, 22, 47-61. doi: 10.1016/j.tetasy.2010.12.019 en
dc.identifier.volume 22 en
dc.identifier.issued 1 en
dc.identifier.startpage 47 en
dc.identifier.endpage 61 en
dc.identifier.issn 0957-4166
dc.identifier.doi 10.1016/j.tetasy.2010.12.019
dc.description.abstract Hydrolase catalysed kinetic resolutions leading to a series of 3-aryl alkanoic acids (≥94% ee) is described. Hydrolysis of the ethyl esters with a series of hydrolases was undertaken to identify biocatalysts that yield the corresponding acids with excellent enantiopurity in each case. Steric and electronic effects on the efficiency and enantioselectivity of the biocatalytic transformation was also explored. en
dc.format.mimetype application/pdf en
dc.language.iso en en
dc.publisher Elsevier en
dc.rights Copyright © 2011 Elsevier Ltd. All rights reserved. NOTICE: this is the author’s version of a work that was accepted for publication in Tetrahedron: Asymmetry. Changes resulting from the publishing process, such as peer review, editing, corrections, structural formatting, and other quality control mechanisms may not be reflected in this document. Changes may have been made to this work since it was submitted for publication. A definitive version was subsequently published in Tetrahedron: Asymmetry, [22, 1,(02/02/2011)] 10.1016/j.tetasy.2010.12.019 en
dc.subject 3-aryl en
dc.subject Alkanoic acid en
dc.subject Hydrolase catalysed en
dc.subject Enantiopurity en
dc.title Lipase catalysed kinetic resolutions of 3-aryl alkanoic acids en
dc.type Article (peer-reviewed) en
dc.internal.authorurl en
dc.internal.authorcontactother Department of Chemistry, Analytical and Biological Chemistry Research Facility, University College Cork, Cork, Ireland. T: +353 (0)21 4901694 en
dc.internal.availability Full text available en
dc.description.version Accepted Version en
dc.internal.rssid 119669269
dc.contributor.funder Irish Research Council for Science Engineering and Technology en
dc.contributor.funder Eli Lilly and Company, United States en
dc.description.status Peer reviewed en
dc.identifier.journaltitle Tetrahedron: Asymmetry en
dc.internal.copyrightchecked Checked Romeo. Also en
dc.internal.IRISemailaddress en

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