Physical activity for health: the impact of exercise on the human gut microbiota and pro-inflammatory cytokines

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dc.contributor.advisor Molloy, Michael G. en
dc.contributor.advisor Shanahan, Fergus en
dc.contributor.author Cronin, Owen
dc.date.accessioned 2018-04-17T10:39:47Z
dc.date.issued 2018
dc.date.submitted 2018
dc.identifier.citation Cronin, O. 2018. Physical activity for health: the impact of exercise on the human gut microbiota and pro-inflammatory cytokines. PhD Thesis, University College Cork. en
dc.identifier.uri http://hdl.handle.net/10468/5789
dc.description.abstract Introduction: Promotion of regular physical activity is a critical tool in the fight against chronic disease. However, our knowledge of the interplay between host organ systems and exercise is limited, preventing us from harnessing the full potential exercise promises in the prevention and treatment of chronic disease. Methods: To maximize our ability to use exercise-related adaptions for health improvement, we focussed on practical and translational areas of Exercise Medicine, centred on 1) the antiinflammatory effects of exercise and 2) the impact of exercise and associated diet on the intestinal microbiota. To do so we used a combination of systematic review, randomized control trials, and prospective observational analyses. Results: Relating to the impact of exercise on the gut microbiome, this work suggests that favourable microbial profiles are evident in the elite athlete in comparison to healthy controls. It is apparent that short-term increases in physical activity are not sufficient to induce major changes in physically inactive individuals. Furthermore, we unearth a relationship between whey protein intake, often used as a dietary adjunct to exercise in recreational and elite sport, and altered diversity of the gut virome. We demonstrate that short-term combined cardiorespiratory and resistance exercise does not lead to significant reductions in the circulating inflammatory biomarker profiles of sedentary individuals or patients with stable inflammatory bowel disease. In contrast, we show that periods of intense exercise, such as those performed during pre-season training in elite sport, alters important components of the innate immune response. Conclusions: Implications of the findings in this thesis are far-reaching and have translational learning points for athletes, patients and physically inactive populations. The work performed underlines the need for further research including the effects of long-term fitness improvement on the gut microbiota and the effects of exercise on disease activity in patients with Inflammatory Bowel Disease. en
dc.format.mimetype application/pdf en
dc.language.iso en en
dc.publisher University College Cork en
dc.rights © 2018, Owen Cronin. en
dc.rights.uri http://creativecommons.org/licenses/by-nc-nd/3.0/ en
dc.subject Microbiome en
dc.subject Exercise en
dc.subject Inflammation en
dc.subject Cytokines en
dc.subject Physical activity en
dc.title Physical activity for health: the impact of exercise on the human gut microbiota and pro-inflammatory cytokines en
dc.type Doctoral thesis en
dc.type.qualificationlevel Doctoral Degree (Structured) en
dc.type.qualificationname PhD (Medicine and Health) en
dc.internal.availability Full text not available en
dc.check.info Restricted to everyone indefinitely en
dc.check.date 10000-01-01T10:39:47Z
dc.description.version Accepted Version
dc.contributor.funder Irish Centre for Arthritis Research and Education (ICARE) en
dc.description.status Not peer reviewed en
dc.internal.school Medicine en
dc.check.reason This thesis is due for publication or the author is actively seeking to publish this material en
dc.check.opt-out Yes en
dc.thesis.opt-out true
dc.check.entireThesis Entire Thesis Restricted
dc.check.embargoformat E-thesis on CORA only en
dc.internal.conferring Summer 2018 en


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© 2018, Owen Cronin. Except where otherwise noted, this item's license is described as © 2018, Owen Cronin.
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