C-reactive protein and radiographic findings of lower respiratory tract infection in infants.

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dc.contributor.author Twomey, Maria
dc.contributor.author Fleming, Hannah
dc.contributor.author Moloney, Fiachra
dc.contributor.author Murphy, Kevin P.
dc.contributor.author Crush, Lee
dc.contributor.author O'Neill, Siobhán B.
dc.contributor.author Flanagan, Oisin
dc.contributor.author Bogue, Conor O.
dc.contributor.author O'Connor, Owen J.
dc.contributor.author Maher, Michael M.
dc.date.accessioned 2018-04-26T10:41:23Z
dc.date.available 2018-04-26T10:41:23Z
dc.date.issued 2017-04-28
dc.identifier.citation Twomey, M., Fleming, H., Moloney, F., Murphy, K. P., Crush, L., O’Neill, S. B., Flanagan, O., James, K., Bogue, C., O’Connor, O. J. and Maher, M. M. (2017) ‘C-reactive protein and radiographic findings of lower respiratory tract infection in infants’, World Journal of Radiology: WJR, 9(4) pp. 206-211. doi:10.4329/wjr.v9.i4.206 en
dc.identifier.volume 9 en
dc.identifier.issued 4 en
dc.identifier.startpage 206 en
dc.identifier.endpage 211 en
dc.identifier.issn 1949-8470
dc.identifier.uri http://hdl.handle.net/10468/5881
dc.identifier.doi 10.4329/wjr.v9.i4.206
dc.description.abstract AIM: To evaluate the association between C-reactive protein (CRP) and radiological evidence of lower respiratory tract infection (LRTI) in infants. METHODS: All patients aged less than 4 years who presented with suspected lower respiratory tract infection, who received a peri-presentation chest radiograph and CRP blood measurement over an 18-mo period were included in the study. Age, gender, source of referral, CRP, white cell count, neutrophil count along with the patients’ symptoms and radiologist’s report were recorded. RESULTS: Three hundred and eleven patients met the inclusion criteria. Abnormal chest radiographs were more common in patients with elevated CRP levels (P < 0.01). Radiologic signs of LRTI were identified in 73.7% of chest radiographs when a patient had a CRP level between 50-99 mg/L. CRP levels were a better predictor of positive chest radiograph findings for those aged greater than I year compared to those 1 year or less. CONCLUSION: CRP may be used in patients with suspected LRTI diagnosis to select those who are likely to have positive findings on chest radiograph, thus reducing unnecessary chest radiographs. Core tip: Abnormal chest radiograph findings are significantly more common in patients with elevated C-reactive protein (CRP) levels. Young children are most likely to have abnormal chest radiograph findings if they have all three of the following; a CRP level of 50-99 mg/L, respiratory symptoms and if they are aged greater than 1 year. en
dc.format.mimetype application/pdf en
dc.language.iso en en
dc.publisher Baishideng Publishing Group en
dc.rights © The Author(s) 2017. Published by Baishideng Publishing Group Inc. All rights reserved. This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ en
dc.rights.uri http://creativecommons.org/licenses/by-nc/4.0/ en
dc.subject Chest radiograph en
dc.subject C-reactive protein en
dc.subject Chest infection en
dc.subject Respiratory infection en
dc.subject Pediatric en
dc.title C-reactive protein and radiographic findings of lower respiratory tract infection in infants. en
dc.type Article (peer-reviewed) en
dc.internal.authorcontactother Owen O'Connor, Medicine , University College Cork, Cork, Ireland. +353-21-490-3000 Email: oj.oconnor@ucc.ie en
dc.internal.availability Full text available en
dc.date.updated 2018-04-23T16:19:08Z
dc.description.version Published Version en
dc.internal.rssid 404668144
dc.description.status Peer reviewed en
dc.identifier.journaltitle Journal of Medical Imaging and Radiation Oncology en
dc.internal.copyrightchecked No !!CORA!! en
dc.internal.licenseacceptance Yes en
dc.internal.IRISemailaddress oj.oconnor@ucc.ie en


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© The Author(s) 2017. Published by Baishideng Publishing Group Inc. All rights reserved. This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ Except where otherwise noted, this item's license is described as © The Author(s) 2017. Published by Baishideng Publishing Group Inc. All rights reserved. This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
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