The neuroendocrinology of the microbiota-gut-brain axis: a behavioural perspective

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dc.contributor.author Cussotto, Sofia
dc.contributor.author Sandhu, Kiran V.
dc.contributor.author Dinan, Timothy G.
dc.contributor.author Cryan, John F.
dc.date.accessioned 2018-05-24T11:32:25Z
dc.date.available 2018-05-24T11:32:25Z
dc.date.issued 2018-05-10
dc.identifier.citation Cussotto, S., Sandhu, K. V., Dinan, T. G. and Cryan, J. F. (2018) 'The Neuroendocrinology of the Microbiota-Gut-Brain Axis: A Behavioural Perspective', Frontiers in Neuroendocrinology, In Press. doi: 10.1016/j.yfrne.2018.04.002 en
dc.identifier.startpage 1 en
dc.identifier.endpage 74 en
dc.identifier.issn 0091-3022
dc.identifier.uri http://hdl.handle.net/10468/6186
dc.identifier.doi 10.1016/j.yfrne.2018.04.002
dc.description.abstract The human gut harbours trillions of symbiotic bacteria that play a key role in programming different aspects of host physiology in health and disease. These intestinal microbes are also key components of the gut-brain axis, the bidirectional communication pathway between the gut and the central nervous system (CNS). In addition, the CNS is closely interconnected with the endocrine system to regulate many physiological processes. An expanding body of evidence is supporting the notion that gut microbiota modifications and/or manipulations may also play a crucial role in the manifestation of specific behavioural responses regulated by neuroendocrine pathways. In this review, we will focus on how the intestinal microorganisms interact with elements of the host neuroendocrine system to modify behaviours relevant to stress, eating behaviour, sexual behaviour, social behaviour, cognition and addiction. en
dc.description.sponsorship Science Foundation Ireland (APC Microbiome Ireland research centre funded by Science Foundation Ireland (SFI), through the Irish Government’s National Development Plan); Health Research Board (HRA_POR/2011/23, HRA_POR/2012/32); en
dc.format.mimetype application/pdf en
dc.language.iso en en
dc.publisher Elsevier en
dc.relation.uri http://www.sciencedirect.com/science/article/pii/S0091302218300396
dc.rights © 2018 Elsevier Inc. All rights reserved. This manuscript version is made available under the CC-BY-NC-ND 4.0 license en
dc.rights.uri http://creativecommons.org/licenses/by-nc-nd/4.0/ en
dc.subject Neuroendocrine system en
dc.subject Hormones en
dc.subject Corticosterone en
dc.subject Stress en
dc.subject HPA axis en
dc.subject Eating behaviour en
dc.subject Sexual behaviour en
dc.subject Social behaviour en
dc.subject Learning en
dc.subject Addiction en
dc.title The neuroendocrinology of the microbiota-gut-brain axis: a behavioural perspective en
dc.type Article (peer-reviewed) en
dc.internal.authorcontactother John F Cryan, Department Of Anatomy & Neuroscience, University College Cork, Cork, Ireland. +353-21-490-3000 Email: j.cryan@ucc.ie en
dc.internal.availability Full text available en
dc.check.info Access to this article is restricted until 18 months after publication by request of the publisher. en
dc.check.date 2019-11-10
dc.date.updated 2018-05-24T11:21:30Z
dc.description.version Accepted Version en
dc.internal.rssid 438880647
dc.contributor.funder Science Foundation Ireland en
dc.contributor.funder Health Research Board en
dc.contributor.funder Seventh Framework Programme en
dc.description.status Peer reviewed en
dc.identifier.journaltitle Frontiers In Neuroendocrinology en
dc.internal.copyrightchecked No !!CORA!! en
dc.internal.licenseacceptance Yes en
dc.internal.IRISemailaddress J.Cryan@ucc.ie en
dc.internal.bibliocheck June 2018. In press. Update citation, volume page numbers etc. en
dc.relation.project info:eu-repo/grantAgreement/SFI/SFI Research Centres/12/RC/2273/IE/Alimentary Pharmabiotic Centre (APC) - Interfacing Food & Medicine/ en
dc.relation.project info:eu-repo/grantAgreement/SFI/SFI Centre for Science Engineering and Technology (CSET)/07/CE/B1368/IE/CSET APC: Alimentary Pharmabiotic Centre - Second Term Funding/ en
dc.relation.project info:eu-repo/grantAgreement/EC/FP7::SP1::HEALTH/201714/EU/Serotonin and GABA-B receptors in anxiety : from developmental risk factors to treatment./DEVANX en


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© 2018 Elsevier Inc. All rights reserved. This manuscript version is made available under the CC-BY-NC-ND 4.0 license Except where otherwise noted, this item's license is described as © 2018 Elsevier Inc. All rights reserved. This manuscript version is made available under the CC-BY-NC-ND 4.0 license
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