Genetic variants related to urate and risk of Parkinson's disease

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dc.contributor.author Hughes, Katherine C.
dc.contributor.author Gao, Xiang
dc.contributor.author O'Reilly, Éilis J.
dc.contributor.author Kim, Iris Y.
dc.contributor.author Wang, Molin
dc.contributor.author Weisskopf, Marc G.
dc.contributor.author Schwarzschild, Michael A.
dc.contributor.author Ascherio, Alberto
dc.date.accessioned 2018-05-24T15:32:38Z
dc.date.available 2018-05-24T15:32:38Z
dc.date.issued 2018-05-01
dc.identifier.citation Hughes, K. C., Gao, X., O'Reilly, E. J., Kim, I. Y., Wang, M., Weisskopf, M. G., Schwarzschild, M. A. and Ascherio, A. (2018) 'Genetic variants related to urate and risk of Parkinson's disease', Parkinsonism & Related Disorders, In Press. doi: 10.1016/j.parkreldis.2018.04.031 en
dc.identifier.startpage 1 en
dc.identifier.endpage 6 en
dc.identifier.issn 1353-8020
dc.identifier.uri http://hdl.handle.net/10468/6191
dc.identifier.doi 10.1016/j.parkreldis.2018.04.031
dc.description.abstract Introduction: Higher urate concentrations have been associated with a lower risk of developing Parkinson's disease (PD) and with slower rates of clinical decline in PD patients. Whether these associations reflect a neuroprotective effect of urate is unclear. Our objective was to assess whether genetic variants that modify circulating urate levels are also associated with altered PD risk. Methods: Participants were from three large ongoing cohort studies: the Nurses' Health Study (NHS), the Health Professionals Follow-up Study (HPFS), and the Cancer Prevention Study II Nutrition Cohort (CPS-IIN). We examined associations between single nucleotide polymorphisms (SNPs) in SLC2A9 and other genes involved in urate transport and PD risk using conditional logistic regression among 1451 cases and 3135 matched controls. We assessed associations between SNPs and plasma urate levels in a subset of 1174 control participants with linear regression models. Results: We found the expected associations between SNPs in SLC2A9 and plasma urate levels among men and women; however, SNPs in other genes tended not to be associated with urate. Each SNP in SLC2A9 explained less than 7% of the variance in plasma urate. We did not find significant associations between the SNPs in SLC2A9 and PD risk among men or women. Conclusion: Our results do not support an association between genetic variants associated with circulating urate levels and risk of PD, but larger investigations are needed to determine whether the modest genetic effects on blood urate contribute to predict PD risk. en
dc.description.sponsorship U.S. Department of Defense (W81XWH-14-0131) en
dc.format.mimetype application/pdf en
dc.language.iso en en
dc.publisher Elsevier en
dc.relation.uri http://www.sciencedirect.com/science/article/pii/S1353802018302190
dc.rights © 2018 Elsevier Ltd. All rights reserved. This manuscript version is made available under the CC-BY-NC-ND 4.0 license. en
dc.rights.uri http://creativecommons.org/licenses/by-nc-nd/4.0/ en
dc.subject Parkinson's disease en
dc.subject Urate en
dc.subject Cohort studies en
dc.subject Urate levels en
dc.title Genetic variants related to urate and risk of Parkinson's disease en
dc.type Article (peer-reviewed) en
dc.internal.authorcontactother Eilis J. O'Reilly, Public Health, University College Cork, Cork, Ireland. +353-21-490-3000 Email: eilis.oreilly@ucc.ie en
dc.internal.availability Full text available en
dc.check.info Access to this article is restricted until 12 months after publication by request of the publisher en
dc.check.date 2019-05-01
dc.description.version Accepted Version en
dc.contributor.funder National Institutes of Health en
dc.contributor.funder U.S. Department of Defense en
dc.description.status Peer reviewed en
dc.identifier.journaltitle Parkinsonism & Related Disorders en
dc.relation.project info:eu-repo/grantAgreement/NIH/NATIONAL CANCER INSTITUTE/5UM1CA186107-02/US/Long Term Multidisciplinary Study of Cancer in Women: The Nurses Health Study/ en
dc.relation.project info:eu-repo/grantAgreement/NIH/NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE/5R01NS061858-03/US/Urate as a Predictor of Parkinsons Disease Risk and Progression/ en


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© 2018 Elsevier Ltd. All rights reserved. This manuscript version is made available under the CC-BY-NC-ND 4.0 license. Except where otherwise noted, this item's license is described as © 2018 Elsevier Ltd. All rights reserved. This manuscript version is made available under the CC-BY-NC-ND 4.0 license.
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