Drug-gut microbiota interactions: implications for neuropharmacology

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dc.contributor.author Walsh, Jacinta
dc.contributor.author Griffin, Brendan T.
dc.contributor.author Clarke, Gerard
dc.contributor.author Hyland, Niall P.
dc.date.accessioned 2018-06-05T08:55:13Z
dc.date.available 2018-06-05T08:55:13Z
dc.date.issued 2018-05-21
dc.identifier.citation Walsh, J., Griffin, B. T., Clarke, G. and Hyland, N. P. (2018) 'Drug-gut microbiota interactions: implications for neuropharmacology', British Journal of Pharmacology. doi:10.1111/bph.14366 en
dc.identifier.issn 0007-1188
dc.identifier.issn 1476-5381
dc.identifier.uri http://hdl.handle.net/10468/6243
dc.identifier.doi 10.1111/bph.14366
dc.description.abstract The fate and activity of drugs are frequently dictated not only by the host per se but also by the microorganisms present in the gastrointestinal tract. The gut microbiome is known to, both directly and indirectly, affect drug metabolism. More evidence now hints at the impact that drugs can have on the function and composition of the gut microbiome. Both microbiota-mediated alterations in drug metabolism and drug-mediated alterations in the gut microbiome can have beneficial or detrimental effects on the host. Greater insights into the mechanisms driving these reciprocal drug-gut microbiota interactions are needed, to guide the development of microbiome-targeted dietary or pharmacological interventions, with the potential to enhance drug efficacy or reduce drug side-effects. In this review, we explore the relationship between drugs and the gut microbiome, with a specific focus on potential mechanisms underpinning the drug-mediated alterations on the gut microbiome and the potential implications for psychoactive drugs. en
dc.format.mimetype application/pdf en
dc.language.iso en en
dc.publisher John Wiley & Sons, Inc. on behalf of the British Pharmacological Society en
dc.rights © 2018, British Pharmacological Society. All rights reserved. Published by John Wiley & Sons Ltd. This is the peer reviewed version of the following article: Walsh, J., Griffin, B. T., Clarke, G. and Hyland, N. P. (2018) 'Drug-gut microbiota interactions: implications for neuropharmacology', British Journal of Pharmacology. doi:10.1111/bph.14366, which has been published in final form at https://doi.org/10.1111/bph.14366. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Self-Archiving. en
dc.subject Drug metabolism en
dc.subject Neuropharmacology en
dc.subject Microbial enzymes en
dc.subject Drug en
dc.subject Microbiome en
dc.title Drug-gut microbiota interactions: implications for neuropharmacology en
dc.type Article (peer-reviewed) en
dc.internal.authorcontactother Brendan Griffin, School Of Pharmacy, University College Cork, Cork, Ireland. +353-21-490-3000 Email: brendan.griffin@ucc.ie en
dc.internal.availability Full text available en
dc.check.info Access to this article is restricted until 12 months after publication by request of the publisher. en
dc.check.date 2019-05-21
dc.date.updated 2018-05-30T09:05:27Z
dc.description.version Accepted Version en
dc.internal.rssid 439639285
dc.contributor.funder Science Foundation Ireland en
dc.description.status Peer reviewed en
dc.identifier.journaltitle British Journal of Pharmacology en
dc.internal.copyrightchecked Yes en
dc.internal.licenseacceptance Yes en
dc.internal.IRISemailaddress brendan.griffin@ucc.ie en
dc.internal.IRISemailaddress n.hyland@ucc.ie en
dc.internal.bibliocheck In press. Check for vol. / issue / page numbers. Amend citation as necessary.
dc.relation.project info:eu-repo/grantAgreement/SFI/SFI Research Centres/12/RC/2273/IE/Alimentary Pharmabiotic Centre (APC) - Interfacing Food & Medicine/ en

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