Cocrystallization of nutraceuticals

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dc.contributor.author Sinha, Abhijeet S.
dc.contributor.author Maguire, Anita R.
dc.contributor.author Lawrence, Simon E.
dc.date.accessioned 2018-06-06T11:23:28Z
dc.date.available 2018-06-06T11:23:28Z
dc.date.issued 2014-12-19
dc.identifier.citation Sinha, A. S., Maguire, A. R. and Lawrence, S. E. (2015) 'Cocrystallization of Nutraceuticals', Crystal Growth & Design, 15(2), pp. 984-1009. doi: 10.1021/cg501009c en
dc.identifier.volume 15 en
dc.identifier.issued 2 en
dc.identifier.startpage 984 en
dc.identifier.endpage 1009 en
dc.identifier.issn 1528-7483
dc.identifier.uri http://hdl.handle.net/10468/6252
dc.identifier.doi 10.1021/cg501009c
dc.description.abstract Cocrystallization has emerged over the past decade as an attractive technique for modification of the physicochemical properties of compounds used as active pharmaceutical ingredients (APIs), complementing more traditional methods such as salt formation. Nutraceuticals, with associated health benefits and/or medicinal properties, are attractive as coformers due to their ready availability, known pharmacological profile, and natural origin, in addition to offering a dual therapy approach. Successful studies of favorably altering the physicochemical properties of APIs through cocrystallization with nutraceuticals are highlighted in this review. Many of the key functional groups commonly seen in nutraceuticals (e.g., acids, phenols) underpin robust supramolecular synthons in crystal engineering. This review assesses the structural data available to date across a diverse range of nutraceuticals, both in pure form and in multicomponent materials, and identifies the persistent supramolecular features present. This insight will ultimately enable predictive and controlled assembly of functional materials incorporating nutraceuticals together with APIs. en
dc.format.mimetype application/pdf en
dc.language.iso en en
dc.publisher American Chemical Society (ACS) en
dc.rights © 2014 American Chemical Society. This document is the Accepted Manuscript version of a Published Work that appeared in final form in Crystal Growth & Design, copyright © American Chemical Society after peer review and technical editing by the publisher. To access the final edited and published work see https://pubs.acs.org/doi/10.1021/cg501009c en
dc.subject Functional groups en
dc.subject Functional materials en
dc.subject Supramolecular chemistry en
dc.subject Active pharmaceutical ingredients en
dc.subject Cocrystallization en
dc.subject Controlled assembly en
dc.subject Multicomponent materials en
dc.subject Pharmacological profiles en
dc.subject Physicochemical property en
dc.subject Supramolecular features en
dc.subject Supramolecular synthons en
dc.title Cocrystallization of nutraceuticals en
dc.type Article (peer-reviewed) en
dc.internal.authorcontactother Simon Lawrence, Chemistry, University College Cork, Cork, Ireland. +353-21-490-3000 Email: simon.lawrence@ucc.ie en
dc.internal.availability Full text available en
dc.date.updated 2018-06-06T10:03:22Z
dc.description.version Accepted Version en
dc.internal.rssid 285909617
dc.description.status Peer reviewed en
dc.identifier.journaltitle Crystal Growth & Design en
dc.internal.copyrightchecked No !!CORA!! en
dc.internal.licenseacceptance Yes en
dc.internal.IRISemailaddress simon.lawrence@ucc.ie en


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