Poor cognitive ageing: vulnerabilities, mechanisms and the impact of nutritional interventions

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dc.contributor.author Miguel, Sophie
dc.contributor.author Champ, Claire
dc.contributor.author Day, Jon
dc.contributor.author Aarts, Esther
dc.contributor.author Bahr, Ben A.
dc.contributor.author Bakker, Martijntje
dc.contributor.author Bánáti, Diana
dc.contributor.author Calabrese, Vittorio
dc.contributor.author Cederholm, Tommy
dc.contributor.author Cryan, John
dc.contributor.author Dye, Louise
dc.contributor.author Farrimond, Jonathan A.
dc.contributor.author Korosi, Aniko
dc.contributor.author Layé, Sophie
dc.contributor.author Maudsley, Stuart
dc.contributor.author Milenkovic, Dragan
dc.contributor.author Mohajeri, M. Hasan
dc.contributor.author Sijben, John
dc.contributor.author Solomon, Alina
dc.contributor.author Spencer, Jeremy P. E.
dc.contributor.author Thuret, Sandrine
dc.contributor.author Vanden Berghe, Wim
dc.contributor.author Vauzour, David
dc.contributor.author Vellas, Bruno
dc.contributor.author Wesnes, Keith
dc.contributor.author Willatts, Peter
dc.contributor.author Wittenberg, Raphael
dc.contributor.author Geurts, Lucie
dc.date.accessioned 2018-06-15T11:47:10Z
dc.date.available 2018-06-15T11:47:10Z
dc.date.issued 2018
dc.identifier.citation Miquel, S., Champ, C., Day, J., Aarts, E., Bahr, B. A., Bakker, M., Bánáti, D., Calabrese, V., Cederholm, T., Cryan, J., Dye, L., Farrimond, J. A., Korosi, A., Layé, S., Maudsley, S., Milenkovic, D., Mohajeri, M. H., Sijben, J., Solomon, A., Spencer, J. P. E., Thuret, S., Vanden Berghe, W., Vauzour, D., Vellas, B., Wesnes, K., Willatts, P., Wittenberg, R. and Geurts, L. (2018) 'Poor cognitive ageing: vulnerabilities, mechanisms and the impact of nutritional interventions', Ageing Research Reviews, 42, pp. 40-55. doi: 10.1016/j.arr.2017.12.004 en
dc.identifier.volume 42
dc.identifier.startpage 40
dc.identifier.endpage 55
dc.identifier.issn 1568-1637
dc.identifier.uri http://hdl.handle.net/10468/6326
dc.identifier.doi 10.1016/j.arr.2017.12.004
dc.description.abstract Background: Ageing is a highly complex process marked by a temporal cascade of events, which promote alterations in the normal functioning of an individual organism. The triggers of normal brain ageing are not well understood, even less so the factors which initiate and steer the neuronal degeneration, which underpin disorders such as dementia. A wealth of data on how nutrients and diets may support cognitive function and preserve brain health are available, yet the molecular mechanisms underlying their biological action in both normal ageing, age-related cognitive decline, and in the development of neurodegenerative disorders have not been clearly elucidated. Objectives: This review aims to summarise the current state of knowledge of vulnerabilities that predispose towards dysfunctional brain ageing, highlight potential protective mechanisms, and discuss dietary interventions that may be used as therapies. A special focus of this paper is on the impact of nutrition on neuroprotection and the underlying molecular mechanisms, and this focus reflects the discussions held during the 2nd workshop 'Nutrition for the Ageing Brain: Functional Aspects and Mechanisms' in Copenhagen in June 2016. The present review is the most recent in a series produced by the Nutrition and Mental Performance Task Force under the auspice of the International Life Sciences Institute Europe (ILSI Europe). Conclusion: Coupling studies of cognitive ageing with studies investigating the effect of nutrition and dietary interventions as strategies targeting specific mechanisms, such as neurogenesis, protein clearance, inflammation, and non-coding and microRNAs is of high value. Future research on the impact of nutrition on cognitive ageing will need to adopt a longitudinal approach and multimodal nutritional interventions will likely need to be imposed in early-life to observe significant impact in older age. en
dc.description.sponsorship International Life Sciences Institute Research Foundation (Europe Nutrition and Mental Performance Task Force) en
dc.format.mimetype application/pdf en
dc.language.iso en en
dc.publisher Elsevier Ltd en
dc.relation.uri https://www.sciencedirect.com/science/article/pii/S1568163717302064
dc.rights © 2017, the Authors. Published by Elsevier B.V. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/BY-NC-ND/4.0/). en
dc.rights.uri http://creativecommons.org/licenses/BY-NC-ND/4.0/
dc.subject Cognition en
dc.subject Preventive diet en
dc.subject Cognitive decline en
dc.subject Neuroprotection en
dc.subject Neuro-inflammation en
dc.subject Plant-food bioactives en
dc.title Poor cognitive ageing: vulnerabilities, mechanisms and the impact of nutritional interventions en
dc.type Review en
dc.internal.authorcontactother John F Cryan, Anatomy & Neuroscience, University College Cork, Cork, Ireland. +353-21-490-3000 Email: j.cryan@ucc.ie en
dc.internal.availability Full text available en
dc.description.version Published Version en
dc.contributor.funder International Life Sciences Institute Research Foundation
dc.description.status Peer reviewed
dc.identifier.journaltitle Ageing Research Reviews en
dc.internal.IRISemailaddress j.cryan@ucc.ie en


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© 2017, the Authors. Published by Elsevier B.V. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/BY-NC-ND/4.0/). Except where otherwise noted, this item's license is described as © 2017, the Authors. Published by Elsevier B.V. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/BY-NC-ND/4.0/).
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