The association of night-time systolic blood pressure with ultrasound markers of subclinical cardiac and vascular disease

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dc.contributor.author O'Flynn, Anne Marie
dc.contributor.author Ho, Emily
dc.contributor.author Dolan, Eamon
dc.contributor.author Curtin, Ronan J.
dc.contributor.author Kearney, Patricia M.
dc.date.accessioned 2018-06-15T11:47:15Z
dc.date.available 2018-06-15T11:47:15Z
dc.date.issued 2017
dc.identifier.citation O’Flynn, A. M., Ho, E., Dolan, E., Curtin, R. J. and Kearney, P. M. (2017) 'The association of night-time systolic blood pressure with ultrasound markers of subclinical cardiac and vascular disease', Blood Pressure Monitoring, 22(1), pp. 18-26. doi: 10.1097/MBP.0000000000000223 en
dc.identifier.volume 22
dc.identifier.issued 1
dc.identifier.startpage 18
dc.identifier.endpage 26
dc.identifier.issn 1359-5237
dc.identifier.uri http://hdl.handle.net/10468/6342
dc.identifier.doi 10.1097/MBP.0000000000000223
dc.description.abstract Introduction The aim of this study was to examine the association of night-time systolic blood pressure (BP) with subclinical cardiac dysfunction measured by global longitudinal strain (GLS) and subclinical vascular damage measured by carotid intima-media thickness (CIMT) and carotid plaques. Methods GLS was measured by speckle-tracking analysis of echocardiogram images. CIMT was measured at the distal 1 cm of the common carotid artery. The presence of carotid plaques was recorded. Philips QLAB cardiac and vascular ultrasound quantification software was used for analysis. The association of night-time systolic BP with GLS, CIMT and carotid plaques was assessed using linear and logistic regression. Results Fifty (response rate 63%) individuals took part in this study. In univariable models, night-time systolic BP was significantly associated with GLS [beta coefficient 0.85 for every 10 mmHg increase, 95% confidence interval (CI): 0.3-1.4] and carotid plaques (odds ratio 1.9 for every 10 mmHg increase, 95% CI: 1.1-3.2). Univariable analysis of daytime systolic BP did not show any statistically significant associations. In age-adjusted and sex-adjusted models, the association for night-time systolic BP and GLS remained significant (beta coefficient 0.68 for every 10 mmHg increase, 95% CI: 0.1-1.3). The association for carotid plaques was no longer statistically significant. In multivariable models, findings were diminished. Discussion Our results suggest a trend towards an association between night-time systolic BP and subclinical cardiac and vascular disease. When assessing ambulatory blood pressure monitoring results, the absolute night-time systolic BP seems to be a better prognostic parameter than daytime systolic BP, but ultimately a large randomised controlled trial involving chronotherapy is necessary to fully address this. Copyright (C) 2017 Wolters Kluwer Health, Inc. All rights reserved. en
dc.description.sponsorship Health Research Board (HPF/2012/14); Irish Heart Foundation (John Feely research bursary) en
dc.format.mimetype application/pdf en
dc.language.iso en en
dc.publisher Lippincott, Williams & Wilkins en
dc.relation.uri https://journals.lww.com/bpmonitoring/Fulltext/2017/02000/The_association_of_night_time_systolic_blood.4.aspx
dc.rights © 2017, the Authors. This is an open-access article distributed under the terms of the Creative Commons Attribution-Non Commercial-No Derivatives License 4.0 (CCBY-NC-ND), where it is permissible to download and share the work provided it is properly cited. The work cannot be changed in any way or used commercially without permission from the journal. http://creativecommons.org/licenses/by-nc-nd/4.0/ en
dc.rights.uri https://creativecommons.org/licenses/by-nc-nd/4.0/
dc.subject Ambulatory blood pressure monitoring en
dc.subject Carotid intima-media thickness en
dc.subject Global longitudinal strain en
dc.subject Hypertension en
dc.subject Ultrasonography en
dc.title The association of night-time systolic blood pressure with ultrasound markers of subclinical cardiac and vascular disease en
dc.type Article (peer-reviewed) en
dc.internal.authorcontactother Anne Marie O'Flynn, Epidemiology and Public Health, University College Cork, Cork, Ireland. +353-21-490-3000 Email: am.oflynn@ucc.ie en
dc.internal.availability Full text available en
dc.description.version Published Version en
dc.contributor.funder Health Research Board
dc.contributor.funder Irish Heart Foundation
dc.description.status Peer reviewed
dc.identifier.journaltitle Blood Pressure Monitoring en
dc.internal.IRISemailaddress am.oflynn@ucc.ie en


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© 2017, the Authors. This is an open-access article distributed under the terms of the Creative Commons Attribution-Non Commercial-No Derivatives License 4.0 (CCBY-NC-ND), where it is permissible to download and share the work provided it is properly cited. The work cannot be changed in any way or used commercially without permission from the journal. http://creativecommons.org/licenses/by-nc-nd/4.0/ Except where otherwise noted, this item's license is described as © 2017, the Authors. This is an open-access article distributed under the terms of the Creative Commons Attribution-Non Commercial-No Derivatives License 4.0 (CCBY-NC-ND), where it is permissible to download and share the work provided it is properly cited. The work cannot be changed in any way or used commercially without permission from the journal. http://creativecommons.org/licenses/by-nc-nd/4.0/
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