Fecal microbiota variation across the lifespan of the healthy laboratory rat

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dc.contributor.author Flemer, Burkhardt
dc.contributor.author Gaci, Nadia
dc.contributor.author Borrel, Guillaume
dc.contributor.author Sanderson, Ian R.
dc.contributor.author Chaudhary, Prem P.
dc.contributor.author Tottey, William
dc.contributor.author O'Toole, Paul W.
dc.contributor.author Brugère, Jean-François
dc.date.accessioned 2018-07-18T11:56:21Z
dc.date.available 2018-07-18T11:56:21Z
dc.date.issued 2017
dc.identifier.citation Flemer, B., Gaci, N., Borrel, G., Sanderson, I. R., Chaudhary, P. P., Tottey, W., O'Toole, P. W. and Brugère, J.-F. (2017) 'Fecal microbiota variation across the lifespan of the healthy laboratory rat', Gut Microbes, 8(5), pp. 428-439. doi: 10.1080/19490976.2017.1334033 en
dc.identifier.volume 8
dc.identifier.issued 5
dc.identifier.startpage 428
dc.identifier.endpage 439
dc.identifier.issn 1949-0976
dc.identifier.uri http://hdl.handle.net/10468/6477
dc.identifier.doi 10.1080/19490976.2017.1334033
dc.description.abstract Laboratory rats are commonly used in life science research as a model for human biology and disease, but the composition and development of their gut microbiota during life is poorly understood. We determined the fecal microbiota composition of healthy Sprague Dawley laboratory rats from 3 weeks to 2 y of age, kept under controlled environmental and dietary conditions. Additionally, we determined fecal short-chain fatty acid profiles, and we compared the rat fecal microbiota with that of mice and humans. Gut microbiota and to a lesser extent SCFAs profiles separated rats into 3 different clusters according to age: before weaning, first year of life (12-to 26-week-old animals) and second year of life (52-to 104-week-old). A core of 46 bacterial species was present in all rats but its members' relative abundance progressively decreased with age. This was accompanied by an increase of microbiota alpha-diversity, likely due to the acquisition of environmental microorganisms during the lifespan. Contrastingly, the functional profile of the microbiota across animal species became more similar upon aging. Lastly, the microbiota of rats and mice were most similar to each other but at the same time the microbiota profile of rats was more similar to that of humans than was the microbiota profile of mice. These data offer an explanation as to why germ-free rats are more efficient recipients and retainers of human microbiota than mice. Furthermore, experimental design should take into account dynamic changes in the microbiota of model animals considering that their changing gut microbiota interacts with their physiology. en
dc.format.mimetype application/pdf en
dc.language.iso en en
dc.publisher Taylor & Francis Inc en
dc.relation.uri https://www.tandfonline.com/doi/full/10.1080/19490976.2017.1334033
dc.rights © 2017, Burkhardt Flemer, Nadia Gaci, Guillaume Borrel, Ian R. Sanderson, Prem P. Chaudhary, William Tottey, Paul W. O’Toole, and Jean-Francois Brugere. Published with license by Taylor & Francis. This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivatives License (http://creativecommons.org/licenses/by-nc-nd/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited, and is not altered, transformed, or built upon in any way en
dc.rights.uri https://creativecommons.org/licenses/by-nc-nd/4.0/
dc.subject Gut microbiota en
dc.subject Human biologic model en
dc.subject Lifespan evolution en
dc.subject Rat en
dc.subject Rattus norvegicus en
dc.title Fecal microbiota variation across the lifespan of the healthy laboratory rat en
dc.type Article (peer-reviewed) en
dc.internal.authorcontactother Paul W. O’Toole, Alimentary Pharmabiotic Centre, University College Cork, Cork, Ireland. +353-21-490-3000 E-mail: pwotoole@ucc.ie en
dc.internal.availability Full text available en
dc.description.version Published Version en
dc.contributor.funder Clermont Université
dc.contributor.funder Conseil Régional d'Auvergne
dc.contributor.funder Ministère de l'Enseignement Supérieur et de la Recherche
dc.contributor.funder Science Foundation Ireland
dc.description.status Peer reviewed en
dc.identifier.journaltitle Gut Microbes en
dc.internal.IRISemailaddress pwotoole@ucc.ie en
dc.relation.project info:eu-repo/grantAgreement/SFI/SFI Research Centres/12/RC/2273/IE/Alimentary Pharmabiotic Centre (APC) - Interfacing Food & Medicine/


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© 2017, Burkhardt Flemer, Nadia Gaci, Guillaume Borrel, Ian R. Sanderson, Prem P. Chaudhary, William Tottey, Paul W. O’Toole, and Jean-Francois Brugere. Published with license by Taylor & Francis. This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivatives License (http://creativecommons.org/licenses/by-nc-nd/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited, and is not altered, transformed, or built upon in any way Except where otherwise noted, this item's license is described as © 2017, Burkhardt Flemer, Nadia Gaci, Guillaume Borrel, Ian R. Sanderson, Prem P. Chaudhary, William Tottey, Paul W. O’Toole, and Jean-Francois Brugere. Published with license by Taylor & Francis. This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivatives License (http://creativecommons.org/licenses/by-nc-nd/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited, and is not altered, transformed, or built upon in any way
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