The immune system and stroke: from current targets to future therapy

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dc.contributor.author Malone, Kyle
dc.contributor.author Amu, Sylvie
dc.contributor.author Moore, Anne C.
dc.contributor.author Waeber, Christian
dc.date.accessioned 2018-07-27T11:03:32Z
dc.date.available 2018-07-27T11:03:32Z
dc.date.issued 2018-07-19
dc.identifier.citation Malone, K., Amu, S., Moore, A. C. and Waeber, C. (2018) 'The immune system and stroke: from current targets to future therapy', Immunology and Cell Biology. doi:10.1111/imcb.12191 en
dc.identifier.issn 0818-9641
dc.identifier.issn 1440-1711
dc.identifier.uri http://hdl.handle.net/10468/6507
dc.identifier.doi 10.1111/imcb.12191
dc.description.abstract Stroke is a major cause of morbidity and mortality worldwide. Despite the intensive search for new therapies, hundreds of agents targeting various pathophysiological mechanisms have failed clinical trials, and the thrombolytic agent tissue plasminogen activator is currently the only FDA-approved medication for the treatment of acute ischaemic stroke (AIS). The immune system is involved in all stages of stroke, from the pathogenesis of risk factors to neurotoxicity, to tissue remodelling and repair. There is a bi-directional interaction between the brain and the immune system, with stroke-induced immunosuppression and subsequent infection a principal source of patient mortality. Newer work also points to a role for the gut microbiota in the immune response to stroke, while clinical sequelae such as dementia might now also be explained in immune terms. However, the exact roles of innate and adaptive components have not been fully elucidated, with studies reporting both detrimental and beneficial functions. Time is a key determinant in defining whether immunity and inflammation are neuroprotective or neurotoxic. The local inflammatory milieu also has a clear influence on many proposed treatments. This review examines the individual components of the immune response to stroke, highlighting the most promising future stroke immunotherapies. en
dc.description.sponsorship Irish Research Council (GOIPG/2017/431); Health Research Board (HRA-POR-2015-1236); Science Foundation Ireland (BIAP2015) en
dc.format.mimetype application/pdf en
dc.language.iso en en
dc.publisher John Wiley & Sons, Inc. en
dc.rights © 2018, John Wiley & Sons Inc. This is the peer reviewed version of the following article: Malone, K., Amu, S., Moore, A. C. and Waeber, C. (2018) 'The immune system and stroke: from current targets to future therapy', Immunology and Cell Biology. doi:10.1111/imcb.12191, which has been published in final form at https://doi.org/10.1111/imcb.12191. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Self-Archiving. en
dc.subject Stroke en
dc.subject Ischaemia en
dc.subject Immunity en
dc.subject Neuroinflammation en
dc.title The immune system and stroke: from current targets to future therapy en
dc.type Article (peer-reviewed) en
dc.internal.authorcontactother Christian Waeber, School Of Pharmacy, University College Cork, Cork, Ireland. +353-21-490-3000 Email: c.waeber@ucc.ie en
dc.internal.availability Full text available en
dc.check.info Access to this article is restricted until 12 months after publication by request of the publisher. en
dc.check.date 2019-07-19
dc.date.updated 2018-07-26T09:08:58Z
dc.description.version Accepted Version en
dc.internal.rssid 447107558
dc.contributor.funder Irish Research Council en
dc.contributor.funder Health Research Board en
dc.contributor.funder Seventh Framework Programme en
dc.contributor.funder Science Foundation Ireland en
dc.description.status Peer reviewed en
dc.identifier.journaltitle Immunology and Cell Biology en
dc.internal.copyrightchecked Yes en
dc.internal.licenseacceptance Yes en
dc.internal.IRISemailaddress c.waeber@ucc.ie en
dc.internal.bibliocheck In press. Check for vol. / issue / page numbers. Amend citation as necessary.
dc.relation.project info:eu-repo/grantAgreement/EC/FP7::SP3::PEOPLE/631246/EU/Sphingosine kinase 2-mediated preconditioning in stroke/SPK AND STROKE en


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