Pure iterative reconstruction improves image quality in computed tomography of the abdomen and pelvis acquired at substantially reduced radiation doses in patients with active Crohn disease

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dc.contributor.author McLaughlin, Patrick D.
dc.contributor.author Murphy, Kevin P.
dc.contributor.author Twomey, Maria
dc.contributor.author O'Neill, Siobhán B.
dc.contributor.author Moloney, Fiachra
dc.contributor.author O'Connor, Owen J.
dc.contributor.author O'Regan, Kevin
dc.contributor.author McSweeney, Sean
dc.contributor.author McGarrigle, Anne Marie
dc.contributor.author Moore, Niamh
dc.contributor.author Bye, Jackie
dc.contributor.author Shanahan, Fergus
dc.contributor.author Maher, Michael M.
dc.date.accessioned 2018-08-14T15:54:59Z
dc.date.available 2018-08-14T15:54:59Z
dc.date.issued 2016-03
dc.identifier.citation McLaughlin, P. D., Murphy, K. P., Twomey, M., O'Neill, S. B., Moloney, F., O'Connor, O. J., O'Regan, K., McSweeney, S., McGarrigle, A. M., Moore, N., Bye, J., Shanahan, F. and Maher, M. M. (2016) 'Pure Iterative Reconstruction Improves Image Quality in Computed Tomography of the Abdomen and Pelvis Acquired at Substantially Reduced Radiation Doses in Patients With Active Crohn Disease', Journal of Computer Assisted Tomography, 40(2), pp. 225-233. doi: 10.1097/RCT.0000000000000358 en
dc.identifier.volume 40 en
dc.identifier.startpage 225 en
dc.identifier.endpage 233 en
dc.identifier.issn 0363-8715
dc.identifier.uri http://hdl.handle.net/10468/6612
dc.identifier.doi 10.1097/RCT.0000000000000358
dc.description.abstract Objective: We assessed diagnostic accuracy and image quality of modified protocol (MP) computed tomography (CT) of the abdomen and pelvis reconstructed using pure iterative reconstruction (IR) in patients with Crohn disease (CD). Methods: Thirty-four consecutive patients with CD were referred with suspected extramural complications. Two contemporaneous CT datasets were acquired in all patients: standard protocol (SP) and MP. The MP and SP protocols were designed to impart radiation exposures of 10% to 20% and 80% to 90% of routine abdominopelvic CT, respectively. The MP images were reconstructed with model-based IR (MBIR) and adaptive statistical IR (ASIR). Results: The MP-CT and SP-CT dose length product were 88 (58) mGy.cm (1.27 [0.87] mSv) and 303 [204] mGy.cm (4.8 [2.99] mSv), respectively (P < 0.001). Median diagnostic acceptability, spatial resolution, and contrast resolution were significantly higher and subjective noise scores were significantly lower on SP-ASIR 40 compared with all MP datasets. There was perfect clinical agreement between MP-MBIR and SP-ASIR 40 images for detection of extramural complications. Conclusions: Modified protocol CT using pure IR is feasible for assessment of active CD. en
dc.format.mimetype application/pdf en
dc.language.iso en en
dc.publisher Lippincott, Williams & Wilkins en
dc.relation.uri https://journals.lww.com/jcat/Fulltext/2016/03000/Pure_Iterative_Reconstruction_Improves_Image.7.aspx
dc.rights © 2016 Wolters Kluwer Health, Inc. All rights reserved. This is the submitted manuscript of an article published in Journal of Computer Assisted Tomography. The published version of record is available at https://journals.lww.com/jcat/Fulltext/2016/03000/Pure_Iterative_Reconstruction_Improves_Image.7.aspx en
dc.subject Iterative reconstruction en
dc.subject Computed tomography (CT) en
dc.subject Crohn disease en
dc.subject Abscess en
dc.subject Radiation dose en
dc.title Pure iterative reconstruction improves image quality in computed tomography of the abdomen and pelvis acquired at substantially reduced radiation doses in patients with active Crohn disease en
dc.type Article (peer-reviewed) en
dc.internal.authorcontactother Owen O'Connor, Medicine , University College Cork, Cork, Ireland. +353-21-490-3000 Email: oj.oconnor@ucc.ie en
dc.internal.availability Full text available en
dc.date.updated 2018-06-20T15:09:33Z
dc.description.version Submitted Version en
dc.internal.rssid 421647415
dc.internal.wokid WOS:000373455100007
dc.description.status Peer reviewed en
dc.identifier.journaltitle Journal of computer assisted tomography en
dc.internal.copyrightchecked No !!CORA!! en
dc.internal.licenseacceptance Yes en
dc.internal.IRISemailaddress oj.oconnor@ucc.ie en


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