Radiologic imaging in cystic fibrosis: cumulative effective dose and changing trends over 2 decades

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dc.contributor.author O'Connell, Oisin J.
dc.contributor.author McWilliams, Sebastian R.
dc.contributor.author McGarrigle, Anne Marie
dc.contributor.author O'Connor, Owen J.
dc.contributor.author Shanahan, Fergus
dc.contributor.author Mullane, David
dc.contributor.author Eustace, Joseph A.
dc.contributor.author Maher, Michael M.
dc.contributor.author Plant, Barry J.
dc.date.accessioned 2018-08-15T10:56:20Z
dc.date.available 2018-08-15T10:56:20Z
dc.date.issued 2015-12-16
dc.identifier.citation O'Connell, O. J., McWilliams, S., McGarrigle, A., O'Connor, O. J., Shanahan, F., Mullane, D., Eustace, J., Maher, M. M. and Plant, B. J. (2012) 'Radiologic Imaging in Cystic Fibrosis: Cumulative Effective Dose and Changing Trends Over 2 Decades', Chest, 141(6), pp. 1575-1583. doi: 10.1378/chest.11-1972 en
dc.identifier.volume 141 en
dc.identifier.issued 6 en
dc.identifier.startpage 1575 en
dc.identifier.endpage 1583 en
dc.identifier.issn 0012-3692
dc.identifier.uri http://hdl.handle.net/10468/6613
dc.identifier.doi 10.1378/chest.11-1972
dc.description.abstract Objective: With the increasing life expectancy for patients with cystic fibrosis (CF), and a known predisposition to certain cancers, cumulative radiation exposure from radiologic imaging is of increasing significance. This study explores the estimated cumulative effective radiation dose over a 17-year period from radiologic procedures and changing trends of imaging modalities over this period. Methods: Estimated cumulative effective dose (CED) from all thoracic and extrathoracic imaging modalities and interventional radiology procedures for both adult and pediatric patients with CF, exclusively attending a nationally designated CF center between 1992-2009 for > 1 year, was determined. The study period was divided into three equal tertiles, and estimated CED attributable to all radiologic procedures was estimated for each tertile. Results: Two hundred thirty patients met inclusion criteria (2,240 person-years of follow-up; 5,596 radiologic procedures). CED was > 75 mSv for one patient (0.43%), 36 patients (15.6%) had a CED between 20 and 75 mSv, 56 patients (24.3%) had a CED between 5 and 20 mSv, and in 138 patients (60%) the CED was estimated to be between 0 and 5 mSv over the study period. The mean annual CED per patient increased consecutively from 0.39 mSv/y to 0.47 mSv/y to 1.67 mSv/y over the tertiles one to three of the study period, respectively (P < .001). Thoracic imaging accounted for 46.9% of the total CED and abdominopelvic imaging accounted for 42.9% of the CED, respectively. There was an associated 5.9-fold increase in the use of all CT scanning per patient (P < .001). Conclusions: This study highlights the increasing exposure to ionizing radiation to patients with CF as a result of diagnostic imaging, primarily attributable to CT scanning. Increased awareness of CED and strategies to reduce this exposure are needed. en
dc.format.mimetype application/pdf en
dc.language.iso en en
dc.publisher Elsevier en
dc.relation.uri http://www.sciencedirect.com/science/article/pii/S0012369212603481
dc.rights © 2012 American College of Chest Physicians. Published by Elsevier. This accepted manuscript version is made available under the CC-BY-NC-ND 4.0 license. en
dc.rights.uri http://creativecommons.org/licenses/by-nc-nd/4.0/ en
dc.subject Computer assisted tomography en
dc.subject Barium meal en
dc.subject Correlation analysis en
dc.subject Cystic fibrosis en
dc.subject Diagnostic imaging en
dc.subject Echography en
dc.subject Fluoroscopy Forced expiratory volume en
dc.subject High resolution computer tomography en
dc.subject Lung angiography en
dc.subject Lung scintiscanning en
dc.subject Radiation dose en
dc.subject Radiation dose distribution en
dc.subject Radiation exposure en
dc.subject Spine radiography en
dc.subject Thorax radiography en
dc.title Radiologic imaging in cystic fibrosis: cumulative effective dose and changing trends over 2 decades en
dc.type Article (peer-reviewed) en
dc.internal.authorcontactother Owen O'Connor, Medicine , University College Cork, Cork, Ireland. +353-21-490-3000 Email: oj.oconnor@ucc.ie en
dc.internal.availability Full text available en
dc.date.updated 2012-09-26T14:40:29Z
dc.description.version Accepted Version en
dc.internal.rssid 160749506
dc.internal.wokid 000282988800514
dc.description.status Peer reviewed en
dc.identifier.journaltitle Chest en
dc.internal.copyrightchecked No !!CORA!! en
dc.internal.licenseacceptance Yes en
dc.internal.IRISemailaddress b.plant@ucc.ie en


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© 2012 American College of Chest Physicians. Published by Elsevier. This accepted manuscript version is made available under the CC-BY-NC-ND 4.0 license. Except where otherwise noted, this item's license is described as © 2012 American College of Chest Physicians. Published by Elsevier. This accepted manuscript version is made available under the CC-BY-NC-ND 4.0 license.
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