Development of low-dose protocols for thin-section CT assessment of cystic fibrosis in pediatric patients.

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dc.contributor.author O'Connor, Owen J.
dc.contributor.author Vandeleur, Moya
dc.contributor.author McGarrigle, Anne Marie
dc.contributor.author Moore, Niamh
dc.contributor.author McWilliams, Sebastian R.
dc.contributor.author McSweeney, Seán E.
dc.contributor.author O'Neill, Michael
dc.contributor.author Ní Chróinín, Muireann
dc.contributor.author Maher, Michael M.
dc.date.accessioned 2018-08-22T14:24:35Z
dc.date.available 2018-08-22T14:24:35Z
dc.date.issued 2010-12-01
dc.identifier.citation O’Connor, O. J., Vandeleur, M., McGarrigle, A. M., Moore, N., McWilliams, S. R., McSweeney, S. E., O’Neill, M., Chroinin, M. N. and Maher, M. M. (2010) 'Development of Low-Dose Protocols for Thin-Section CT Assessment of Cystic Fibrosis in Pediatric Patients', Radiology, 257(3), pp. 820-829. doi:10.1148/radiol.10100278 en
dc.identifier.volume 257 en
dc.identifier.issued 3 en
dc.identifier.startpage 820 en
dc.identifier.endpage 829 en
dc.identifier.issn 0033-8419
dc.identifier.issn 1527-1315
dc.identifier.uri http://hdl.handle.net/10468/6635
dc.identifier.doi 10.1148/radiol.10100278
dc.description.abstract Purpose: To develop low-dose thin-section computed tomographic (CT) protocols for assessment of cystic fibrosis (CF) in pediatric patients and determine the clinical usefulness thereof compared with chest radiography. Materials and Methods: After institutional review board approval and informed consent from patients or guardians were obtained, 14 patients with CF and 11 patients without CF (16 male, nine female; mean age, 12.6 years ± 5.4 [standard deviation]; range, 3.5–25 years) who underwent imaging for clinical reasons underwent low-dose thin-section CT. Sections 1 mm thick (protocol A) were used in 10 patients, and sections 0.5 mm thick (protocol B) were used in 15 patients at six levels at 120 kVp and 30–50 mA. Image quality and diagnostic acceptability were scored qualitatively and quantitatively by two radiologists who also quantified disease severity at thin-section CT and chest radiography. Effective doses were calculated by using a CT dosimetry calculator. Results: Low-dose thin-section CT was performed with mean effective doses of 0.19 mSv ± 0.03 for protocol A and 0.14 mSv ± 0.04 for protocol B (P < .005). Diagnostic acceptability and depiction of bronchovascular structures at lung window settings were graded as almost excellent for both protocols, but protocol B was inferior to protocol A for mediastinal assessment (P < .02). Patients with CF had moderate lung disease with a mean Bhalla score of 9.2 ± 5.3 (range, 0–19), compared with that of patients without CF (1.1 ± 1.4; P < .001). There was excellent correlation between thin-section CT and chest radiography (r = 0.88–0.92; P < .001). Conclusion: Low-dose thin-section CT can be performed at lower effective doses than can standard CT, approaching those of chest radiography. Low-dose thin-section CT could be appropriate for evaluating bronchiectasis in pediatric patients, yielding appropriate information about lung parenchyma and bronchovascular structures. en
dc.format.mimetype application/pdf en
dc.language.iso en en
dc.publisher Radiological Society of North America (RSNA) en
dc.relation.uri https://pubs.rsna.org/doi/abs/10.1148/radiol.10100278
dc.rights © RSNA, 2010. Note: This copy is for your personal, non-commercial use only. To order presentation-ready copies for distribution to your colleagues or clients, contact www.rsna.org/rsnarights. en
dc.subject Cystic fibrosis en
dc.subject Prospective studies en
dc.subject Radiation dosage en
dc.subject Radiography, thoracic en
dc.subject Statistics, nonparametric en
dc.subject Tomography, x-Ray computed en
dc.subject Computer assisted tomography en
dc.subject Cystic fibrosis en
dc.subject Diagnostic value en
dc.subject Disease severity en
dc.subject Dosimetry en
dc.subject Image analysis en
dc.subject Image quality en
dc.subject Low energy radiation en
dc.subject Lung structure en
dc.subject Thorax radiography en
dc.title Development of low-dose protocols for thin-section CT assessment of cystic fibrosis in pediatric patients. en
dc.type Article (peer-reviewed) en
dc.internal.authorcontactother Owen O'Connor, Medicine , University College Cork, Cork, Ireland. +353-21-490-3000 Email: oj.oconnor@ucc.ie en
dc.internal.availability Full text available en
dc.date.updated 2018-06-20T16:31:44Z
dc.description.version Published Version en
dc.internal.rssid 67959704
dc.internal.pmid 20876388
dc.description.status Peer reviewed en
dc.identifier.journaltitle Radiology en
dc.internal.copyrightchecked No !!CORA!! en
dc.internal.licenseacceptance Yes en
dc.internal.IRISemailaddress oj.oconnor@ucc.ie en


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