Further elucidation of galactose utilization in Lactococcus lactis MG1363

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dc.contributor.author Solopova, Ana
dc.contributor.author Bachman, Herwig
dc.contributor.author Teusink, Bas
dc.contributor.author Kok, Jan
dc.contributor.author Kuipers, Oscar P.
dc.date.accessioned 2018-08-29T15:47:18Z
dc.date.available 2018-08-29T15:47:18Z
dc.date.issued 2018
dc.identifier.citation Solopova, A., Bachmann, H., Teusink, B., Kok, J. and Kuipers, O. P. (2018) 'Further elucidation of galactose utilization in Lactococcus lactis MG1363', Frontiers in Microbiology, 9, 1803 (9pp). doi: 10.3389/fmicb.2018.01803 en
dc.identifier.volume 9
dc.identifier.startpage 1
dc.identifier.endpage 9
dc.identifier.issn 1664-302X
dc.identifier.uri http://hdl.handle.net/10468/6656
dc.identifier.doi 10.3389/fmicb.2018.01803
dc.description.abstract Since the 1970s, galactose metabolism in Lactococcus lactis has been in debate. Different studies led to diverse outcomes making it difficult to conclude whether galactose uptake was PEP- or ATP-dependent and decide what the exact connection was between galactose and lactose uptake and metabolism. It was shown that some Lactococcus strains possess two galactose-specific systems - a permease and a PTS, even if they lack the lactose utilization plasmid, proving that a lactose-independent PTSGal exists. However, the PTSGal transporter was never identified. Here, with the help of transcriptome analyses and genetic knock-out mutants, we reveal the identities of two low-affinity galactose PTSs. A novel plant-niche-related PTS component Llmg_0963 forming a hybrid transporter Llmg_0963PtcBA and a glucose/mannose-specific PTS are shown to be involved in galactose transport in L. lactis MG1363. en
dc.description.sponsorship Nederlandse Organisatie voor Wetenschappelijk Onderzoek - Stichting voor de Technische Wetenschappen (10619) en
dc.format.mimetype application/pdf en
dc.language.iso en en
dc.publisher Frontiers Media S.A. en
dc.relation.uri https://www.frontiersin.org/articles/10.3389/fmicb.2018.01803/full
dc.rights © 2018, the Authors. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. en
dc.rights.uri https://creativecommons.org/licenses/by/4.0/
dc.subject Galactose transporter en
dc.subject PTS en
dc.subject PEP-transferase system en
dc.subject Lactococcus lactis en
dc.subject GalP en
dc.title Further elucidation of galactose utilization in Lactococcus lactis MG1363 en
dc.type Article (peer-reviewed) en
dc.internal.authorcontactother Ana Solopova, APC Microbiome Institute, University College Cork, Cork, Ireland. +353-21-490-3000 E-mail: ana.solopovabuivyde@ucc.ie en
dc.internal.availability Full text available en
dc.description.version Published Version en
dc.contributor.funder Nederlandse Organisatie voor Wetenschappelijk Onderzoek
dc.contributor.funder Stichting voor de Technische Wetenschappen
dc.description.status Peer reviewed en
dc.identifier.journaltitle Frontiers in Microbiology en
dc.internal.IRISemailaddress ana.solopovabuivyde@ucc.ie en
dc.identifier.articleid 1803


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© 2018, the Authors. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. Except where otherwise noted, this item's license is described as © 2018, the Authors. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
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