Estimation of the maternal vitamin D intake that maintains circulating 25-hydroxyvitamin D in late gestation at a concentration sufficient to keep umbilical cord sera >= 25-30 nmol/L: a dose-response, double-blind, randomized placebo-controlled trial in pregnant women at northern latitude

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dc.contributor.author O'Callaghan, Karen M.
dc.contributor.author Hennessy, Áine
dc.contributor.author Hull, George L. J.
dc.contributor.author Healy, Karina
dc.contributor.author Ritz, Christian
dc.contributor.author Kenny, Louise C.
dc.contributor.author Cashman, Kevin D.
dc.contributor.author Kiely, Mairead E.
dc.date.accessioned 2018-08-29T15:47:29Z
dc.date.available 2018-08-29T15:47:29Z
dc.date.issued 2018
dc.identifier.citation O'Callaghan, K. M., Hennessy, Á., Hull, G. L. J., Healy, K., Ritz, C., Kenny, L. C., Cashman, K. D. and Kiely, M. E. (2018) 'Estimation of the maternal vitamin D intake that maintains circulating 25-hydroxyvitamin D in late gestation at a concentration sufficient to keep umbilical cord sera ≥25–30 nmol/L: a dose-response, double-blind, randomized placebo-controlled trial in pregnant women at northern latitude', The American Journal of Clinical Nutrition, 108(1), pp. 77-91. doi: 10.1093/ajcn/nqy064 en
dc.identifier.volume 108
dc.identifier.issued 1
dc.identifier.startpage 77
dc.identifier.endpage 91
dc.identifier.issn 0002-9165
dc.identifier.uri http://hdl.handle.net/10468/6683
dc.identifier.doi 10.1093/ajcn/nqy064
dc.description.abstract Background: In the absence of dose-response data, Dietary Reference Values for vitamin D in nonpregnant adults are extended to pregnancy. Objective: The aim was to estimate vitamin D intake needed to maintain maternal 25-hydroxyvitamin D [25(OH)D] in late gestation at a concentration sufficient to prevent newborn 25(OH)D <25-30 nmol/L, a threshold indicative of increased risk of nutritional rickets. Design: We conducted a 3-arm, dose-response, double-blind, randomized placebo-controlled trial in Cork, Ireland (51.9 degrees N). A total of 144 white-skinned pregnant women were assigned to receive 0, 10 (400 IU), or 20 (800 IU) mu g vitamin D-3/d from <= 18 wk of gestation. Vitamin D metabolites at 14, 24, and 36 wk of gestation and in cord sera, including 25(OH)D-3, 3-epi-25(OH)D-3, 24,25(OH)(2)D-3, and 25(OH)D-2 were quantified by liquid chromatography-tandem mass spectrometry. A curvilinear regression model predicted the total vitamin D intake (from diet and antenatal supplements plus treatment dose) that maintained maternal 25(OH)D in late gestation at a concentration sufficient to maintain cord 25(OH)D at >= 25-30 nmol/L. Results: Mean +/- SD baseline 25(OH)D was 54.9 +/- 10.7 nmol/L. Total vitamin D intakes at the study endpoint (36 wk of gestation) were 12.1 +/- 8.0, 21.9 +/- 5.3, and 33.7 +/- 5.1 mu g/d in the placebo and 10-mu g and 20-mu g vitamin D-3 groups, respectively; and 25(OH)D was 24.3 +/- 5.8 and 29.2 +/- 5.6 nmol/L higher in the 10- and 20-mu g groups, respectively, compared with placebo (P < 0.001). For maternal 25(OH)D concentrations >= 50 nmol/L, 95% of cord sera were >= 30 nmol/L and 99% were > 25 nmol/L. The estimated vitamin D intake required to maintain serum 25(OH)D at >= 50 nmol/L in 97.5% of women was 28.9 mu g/d. Conclusions: Thirty micrograms of vitamin D per day safely maintained serum 25(OH)D concentrations at >= 50 nmol/L in almost all white-skinned women during pregnancy at a northern latitude, which kept 25(OH)D at > 25 nmol/L in 99% and >= 30 nmol/L in 95% of umbilical cord sera. en
dc.format.mimetype application/pdf en
dc.language.iso en en
dc.publisher Oxford University Press en
dc.relation.uri https://academic.oup.com/ajcn/article/108/1/77/5033927
dc.rights © 2018, American Society for Nutrition. This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0/), which permits noncommercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited. For commercial re-use, please contact journals.permissions@oup.com en
dc.rights.uri http://creativecommons.org/licenses/by-nc/4.0/
dc.subject 25-hydroxyvitamin D en
dc.subject dietary requirements en
dc.subject dose-response en
dc.subject ODIN en
dc.subject Neonatal en
dc.subject Pregnancy en
dc.subject Randomized controlled trial en
dc.subject Vitamin D en
dc.subject Vitamin D requirements en
dc.title Estimation of the maternal vitamin D intake that maintains circulating 25-hydroxyvitamin D in late gestation at a concentration sufficient to keep umbilical cord sera >= 25-30 nmol/L: a dose-response, double-blind, randomized placebo-controlled trial in pregnant women at northern latitude en
dc.type Article (peer-reviewed) en
dc.internal.authorcontactother Mairead Kiely, Food & Nutritional Sciences, University College Cork, Cork, Ireland. +353-21-490-3000 Email: m.kiely@ucc.ie en
dc.internal.availability Full text available en
dc.description.version Published Version en
dc.contributor.funder European Commission
dc.description.status Peer reviewed en
dc.identifier.journaltitle American Journal of Clinical Nutrition en
dc.internal.IRISemailaddress m.kiely@ucc.ie en
dc.relation.project info:eu-repo/grantAgreement/EC/FP7::SP1::KBBE/613977/EU/Food-based solutions for Optimal vitamin D Nutrition and health through the life cycle/ODIN


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© 2018, American Society for Nutrition. This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0/), which permits noncommercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited. For commercial re-use, please contact journals.permissions@oup.com Except where otherwise noted, this item's license is described as © 2018, American Society for Nutrition. This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0/), which permits noncommercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited. For commercial re-use, please contact journals.permissions@oup.com
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