• Pro-survival redox signalling in progesterone-mediated retinal neuroprotection 

  Ruiz Lopez, Ana M.; Roche, Sarah L.; Wyse Jackson, Alice C.; Moloney, Jennifer N.; Byrne, Ashleigh M.; Cotter, Thomas G. (John Wiley & Sons, Inc., 2017-06-08)

  Retinitis pigmentosa (RP) is a group of hereditary retinal diseases, characterised by photoreceptor cell loss. Despite a substantial understanding of the mechanisms leading to cell death, an effective therapeutic strategy ...
• Subcellular localization of the FLT3-ITD oncogene plays a significant role in the production of NOX- and p22phox-derived reactive oxygen species in acute myeloid leukemia 

  Moloney, Jennifer N.; Stanicka, Joanna; Cotter, Thomas G. (Elsevier Ltd., 2017-11-11)

  Internal tandem duplication of the juxtamembrane domain of FMS-like tyrosine kinase 3 (FLT3-ITD) receptor is the most prevalent FLT3 mutation accounting for 20% of acute myeloid leukemia (AML) patients. FLT3-ITD mutation ...
• Leukocyte Bim deficiency does not impact atherogenesis in ldlr -/- mice, despite a pronounced induction of autoimmune inflammation 

  Temmerman, Lieve; Westra, Marijke M.; Bot, Ilze; van Vlijmen, Bart J. M.; Van Bree, Niek; Bot, Martine; Habets, Kim L. L.; Keulers, Tom G. H.; van der Vlag, Johan; Cotter, Thomas G.; van Berkel, Theo J. C.; Biessen, Erik A. L. (Nature Publishing Group, 2017-06-08)

  Proapoptotic Bcl-2 family member Bim is particularly relevant for deletion of autoreactive and activated T and B cells, implicating Bim in autoimmunity. As atherosclerosis is a chronic inflammatory process with features ...
• Steering surface topographies of electrospun fibers: understanding the mechanisms 

  Yazgan, Gökçe; Dmitriev, Ruslan I.; Tyagi, Vasundhara; Jenkins, James; Rotaru, Gelu-Marius; Rottmar, Markus; Rossi, René M.; Toncelli, Claudio; Papkovsky, Dmitri B.; Maniura-Weber, Katharina; Fortunato, Giuseppino (Nature Publishing Group, 2017-03-13)

  A profound understanding of how to tailor surface topographies of electrospun fibers is of great importance for surface sensitive applications including optical sensing, catalysis, drug delivery and tissue engineering. ...
• Fractalkine-CX3CR1 signaling is critical for progesterone-mediated neuroprotection in the retina 

  Roche, Sarah L.; Wyse-Jackson, Alice C.; Ruiz-Lopez, Ana M.; Byrne, Ashleigh M.; Cotter, Thomas G. (Nature Publishing Group, 2017-02-20)

  Retinitis pigmentosa (RP) encompasses a group of retinal diseases resulting in photoreceptor loss and blindness. We have previously shown in the rd10 mouse model of RP, that rd10 microglia drive degeneration of viable ...

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