• Leukocyte Bim deficiency does not impact atherogenesis in ldlr -/- mice, despite a pronounced induction of autoimmune inflammation 

  Temmerman, Lieve; Westra, Marijke M.; Bot, Ilze; van Vlijmen, Bart J. M.; Van Bree, Niek; Bot, Martine; Habets, Kim L. L.; Keulers, Tom G. H.; van der Vlag, Johan; Cotter, Thomas G.; van Berkel, Theo J. C.; Biessen, Erik A. L. (Nature Publishing Group, 2017-06-08)

  Proapoptotic Bcl-2 family member Bim is particularly relevant for deletion of autoreactive and activated T and B cells, implicating Bim in autoimmunity. As atherosclerosis is a chronic inflammatory process with features ...
• Steering surface topographies of electrospun fibers: understanding the mechanisms 

  Yazgan, Gökçe; Dmitriev, Ruslan I.; Tyagi, Vasundhara; Jenkins, James; Rotaru, Gelu-Marius; Rottmar, Markus; Rossi, René M.; Toncelli, Claudio; Papkovsky, Dmitri B.; Maniura-Weber, Katharina; Fortunato, Giuseppino (Nature Publishing Group, 2017-03-13)

  A profound understanding of how to tailor surface topographies of electrospun fibers is of great importance for surface sensitive applications including optical sensing, catalysis, drug delivery and tissue engineering. ...
• Fractalkine-CX3CR1 signaling is critical for progesterone-mediated neuroprotection in the retina 

  Roche, Sarah L.; Wyse-Jackson, Alice C.; Ruiz-Lopez, Ana M.; Byrne, Ashleigh M.; Cotter, Thomas G. (Nature Publishing Group, 2017-02-20)

  Retinitis pigmentosa (RP) encompasses a group of retinal diseases resulting in photoreceptor loss and blindness. We have previously shown in the rd10 mouse model of RP, that rd10 microglia drive degeneration of viable ...
• Characterisation of Schizosaccharomyces pombe α-actinin 

  Addario, Barbara; Sandblad, Linda; Persson, Karina; Backman, Lars (PeerJ, 2016-03-28)

  The actin cytoskeleton plays a fundamental role in eukaryotic cells. Its reorganization is regulated by a plethora of actin-modulating proteins, such as a-actinin. In higher organisms, α-actinin is characterized by the ...
• Decreased anxiety-related behaviour but apparently unperturbed NUMB function in ligand of NUMB protein-X (LNX) 1/2 double knockout mice 

  Lenihan, Joan A.; Saha, Orthis; Heimer-McGinn, Victoria; Cryan, John F.; Feng, Guoping; Young, Paul W. (Springer Science+Business Media, 2016-11-26)

  NUMB is a key regulator of neurogenesis and neuronal differentiation that can be ubiquitinated and targeted for proteasomal degradation by ligand of numb protein-X (LNX) family E3 ubiquitin ligases. However, our understanding ...

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