Dietary conjugated linoleic acid-enriched cheeses influence the levels of circulating n-3 highly unsaturated fatty acids in humans

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dc.contributor.author Murru, Elisabetta
dc.contributor.author Carta, Gianfranca
dc.contributor.author Cordeddu, Lina
dc.contributor.author Melis, Maria Paola
dc.contributor.author Desogus, Erika
dc.contributor.author Ansar, Hastimansooreh
dc.contributor.author Chilliard, Yves
dc.contributor.author Ferlay, Anne
dc.contributor.author Stanton, Catherine
dc.contributor.author Coakley, Mairead
dc.contributor.author Ross, R. Paul
dc.contributor.author Piredda, Giovanni
dc.contributor.author Addis, Margherita
dc.contributor.author Mele, Maria Cristina
dc.contributor.author Cannelli, Giorgio
dc.contributor.author Banni, Sebastiano
dc.contributor.author Manca, Claudia
dc.date.accessioned 2018-09-20T15:53:43Z
dc.date.available 2018-09-20T15:53:43Z
dc.date.issued 2018
dc.identifier.citation Murru, E., Carta, G., Cordeddu, L., Melis, M., Desogus, E., Ansar, H., Chilliard, Y., Ferlay, A., Stanton, C., Coakley, M., Ross, R., Piredda, G., Addis, M., Mele, M., Cannelli, G., Banni, S. and Manca, C. (2018) 'Dietary conjugated linoleic acid-enriched cheeses influence the levels of circulating n-3 highly unsaturated fatty acids in humans', International Journal of Molecular Sciences, 19(6), 1730 (16pp). doi: 10.3390/ijms19061730 en
dc.identifier.volume 19
dc.identifier.issued 6
dc.identifier.startpage 1
dc.identifier.endpage 16
dc.identifier.issn 1422-0067
dc.identifier.uri http://hdl.handle.net/10468/6837
dc.identifier.doi 10.3390/ijms19061730
dc.description.abstract n-3 highly unsaturated fatty acids (n-3 HUFA) directly and indirectly regulate lipid metabolism, energy balance and the inflammatory response. We investigated changes to the n-3 HUFA score of healthy adults, induced by different types and amounts of conjugated linoleic acid (CLA)-enriched (ENCH) cheeses consumed for different periods of time, compared to dietary fish oil (FO) pills (500 mg, each containing 100 mg of eicosapentaenoic and docosahexaenoic acidsEPA+DHA) or -linolenic acid (ALA)-rich linseed oil (4 g, containing 2 g of ALA). A significant increase in the n-3 HUFA score was observed, in a dose-dependent manner, after administration of the FO supplement. In terms of the impact on the n-3 HUFA score, the intake of ENCH cheese (90 g/day) for two or four weeks was equivalent to the administration of one or two FO pills, respectively. Conversely, the linseed oil intake did not significantly impact the n-3 HUFA score. Feeding ENCH cheeses from different sources (bovine, ovine and caprine) for two months improved the n-3 HUFA score by increasing plasma DHA, and the effect was proportional to the CLA content in the cheese. We suggest that the improved n-3 HUFA score resulting from ENCH cheese intake may be attributed to increased peroxisome proliferator-activated receptor alpha (PPAR-) activity. This study demonstrates that natural ENCH cheese is an alternative nutritional source of n-3 HUFA in humans. en
dc.description.sponsorship Fifth Framework Programme (QLK1-2002-02362); European Regional Development Fund (INNOVA.RE-WP 2.3-P.O.R.-F.E.S.R.) en
dc.format.mimetype application/pdf en
dc.language.iso en en
dc.publisher MDPI en
dc.relation.uri http://www.mdpi.com/1422-0067/19/6/1730
dc.rights © 2018, the Authors. Licensee MDPI, Basel, Switzerland. This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0). en
dc.rights.uri https://creativecommons.org/licenses/by/4.0/
dc.subject Conjugated linoleic acids (CLA) en
dc.subject Cheese en
dc.subject Ruminant en
dc.subject Highly unsaturated fatty acids (HUFA) en
dc.subject Fatty acids (FA) en
dc.subject Plasma en
dc.subject Clinical trial en
dc.title Dietary conjugated linoleic acid-enriched cheeses influence the levels of circulating n-3 highly unsaturated fatty acids in humans en
dc.type Article (peer-reviewed) en
dc.internal.authorcontactother Paul Ross, College Of Sefs Office, University College Cork, Cork, Ireland. +353-21-490-3000 Email: p.ross@ucc.ie en
dc.internal.availability Full text available en
dc.description.version Published Version en
dc.contributor.funder Fifth Framework Programme
dc.contributor.funder Science Foundation Ireland
dc.contributor.funder European Regional Development Fund
dc.description.status Peer reviewed en
dc.identifier.journaltitle International Journal of Molecular Sciences en
dc.internal.IRISemailaddress p.ross@ucc.ie en
dc.identifier.articleid 1730
dc.relation.project info:eu-repo/grantAgreement/SFI/SFI Research Centres/12/RC/2273/IE/Alimentary Pharmabiotic Centre (APC) - Interfacing Food & Medicine/


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© 2018, the Authors. Licensee MDPI, Basel, Switzerland. This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0). Except where otherwise noted, this item's license is described as © 2018, the Authors. Licensee MDPI, Basel, Switzerland. This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).
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