Viromes of one year old infants reveal the impact of birth mode on microbiome diversity

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Date
2018
Authors
McCann, Angela
Ryan, Feargal J.
Stockdale, Stephen R.
Dalmasso, Marion
Blake, Tony
Ryan, C. Anthony
Stanton, Catherine
Mills, Susan
Ross, R. Paul
Hill, Colin
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Publisher
PeerJ, Inc
Published Version
10.7717/peerj.4694
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Abstract
Establishing a diverse gut microbiota after birth is being increasingly recognised as important for preventing illnesses later in life. It is well established that bacterial diversity rapidly increases post-partum; however, few studies have examined the infant gut virome/phageorne during this developmental period. We performed a metagenornic analysis of 20 infant faecal viromes at one year of age to determine whether spontaneous vaginal delivery (SVD) or caesarean section (CS) influenced viral composition. We find that birth mode results in distinctly different viral communities, with SVD infants having greater viral and bacteriophage diversity. We demonstrate that CrAssp age is acquired early in life, both in this cohort and two others, althoughno difference in birth mode is detected. A previous study has shown that bacterial OTU's (operational taxonomic units) identified in the same infants could not discriminate between birth mode at 12 months of age. Therefore, our results indicate that vertical transmission of viral communities from mother to child may play a role in shaping the early life microbiome, and that birth mode should be considered when studying the early life gut virome.
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Keywords
Virome , Infant , Birth mode , Bacteriophage , Metagenomics , Microbiome
Citation
McCann, A., Ryan, F. J., Stockdale, S. R., Dalmasso, M., Blake, T., Ryan, C. A., Stanton, C., Mills, S., Ross, P. R. and Hill, C. (2018) 'Viromes of one year old infants reveal the impact of birth mode on microbiome diversity', PeerJ, 6, e4694 (13pp). doi: 10.7717/peerj.4694
URI
http://hdl.handle.net/10468/6871
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APC Microbiome Institute- Journal Articles
Microbiology - Journal Articles
Copyright
© 2018, McCann et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, reproduction and adaptation in any medium and for any purpose provided that it is properly attributed. For attribution, the original author(s), title, publication source (PeerJ) and either DOI or URL of the article must be cited.