Deep tissue imaging with acousto-optical tomography and spectral hole burning with slow light effect: a theoretical study

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dc.contributor.author Gunther, Jacqueline E.
dc.contributor.author Walther, Andreas
dc.contributor.author Rippe, Lars
dc.contributor.author Kröll, Stefan
dc.contributor.author Andersson-Engels, Stefan
dc.date.accessioned 2018-09-24T12:37:00Z
dc.date.available 2018-09-24T12:37:00Z
dc.date.issued 2018
dc.identifier.citation Gunther, J. E., Walther, A., Rippe, L., Kröll, S. and Andersson-Engels, S. (2018) 'Deep tissue imaging with acousto-optical tomography and spectral hole burning with slow light effect: a theoretical study', Journal of Biomedical Optics, 23(7), 071209 (8pp). doi: 10.1117/1.JBO.23.7.071209 en
dc.identifier.volume 23
dc.identifier.issued 7
dc.identifier.startpage 1
dc.identifier.endpage 8
dc.identifier.issn 1083-3668
dc.identifier.issn 1560-2281
dc.identifier.uri http://hdl.handle.net/10468/6882
dc.identifier.doi 10.1117/1.JBO.23.7.071209
dc.description.abstract Biological tissue is a highly scattering medium that prevents deep imaging of light. For medical applications, optical imaging offers a molecular sensitivity that would be beneficial for diagnosing and monitoring of diseases. Acousto-optical tomography has the molecular sensitivity of optical imaging with the resolution of ultrasound and has the potential for deep tissue imaging. Here, we present a theoretical study of a system that combines acousto-optical tomography and slow light spectral filters created using spectral hole burning methods. Using Monte Carlo simulations, a model to obtain the contrast-to-noise ratio (CNR) deep in biological tissue was developed. The simulations show a CNR  >  1 for imaging depths of ∼5  cm in a reflection mode setup, as well as, imaging through ∼12 cm in transmission mode setups. These results are promising and form the basis for future experimental studies. en
dc.format.mimetype application/pdf en
dc.language.iso en en
dc.publisher Society of Photo-optical Instrumentation Engineers (SPIE) en
dc.relation.uri https://www.spiedigitallibrary.org/journals/journal-of-biomedical-optics/volume-23/issue-07/071209/Deep-tissue-imaging-with-acousto-optical-tomography-and-spectral-hole/10.1117/1.JBO.23.7.071209.full?SSO=1
dc.rights © The Authors. Published by SPIE under a Creative Commons Attribution 3.0 Unported License. Distribution or reproduction of this work in whole or in part requires full attribution of the original publication, including its DOI en
dc.subject Biological tissue en
dc.subject Optical imaging en
dc.subject Acousto-optical tomography en
dc.subject Deep tissue imaging en
dc.subject Slow light spectral filter en
dc.title Deep tissue imaging with acousto-optical tomography and spectral hole burning with slow light effect: a theoretical study en
dc.type Article (peer-reviewed) en
dc.internal.authorcontactother Jacqueline Gunther, Tyndall National Institute, University College Cork, Cork, Ireland +353-21-490-3000 Email: jacqueline.gunther@tyndall.ie en
dc.internal.availability Full text available en
dc.description.version Published Version en
dc.contributor.funder Science Foundation Ireland
dc.contributor.funder Knut och Alice Wallenbergs Stiftelse
dc.description.status Peer reviewed en
dc.identifier.journaltitle Journal of Biomedical Optics en
dc.internal.IRISemailaddress jacqueline.gunther@tyndall.ie en
dc.identifier.articleid 71209
dc.relation.project info:eu-repo/grantAgreement/SFI/SFI Research Professorship Programme/15/RP/2828/IE/Novel applications and techniques for in vivo optical imaging and spectroscopy/


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